English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  31P CSI of the human brain in healthy subjects and tumor patients at 9.4 T with a three-layered multi-nuclear coil: initial results

Mirkes, C., Shajan, G., Chadzynski, G., Buckenmaier, K., Bender, B., & Scheffler, K. (2016). 31P CSI of the human brain in healthy subjects and tumor patients at 9.4 T with a three-layered multi-nuclear coil: initial results. Magnetic Resonance Materials in Physics, Biology and Medicine, 29(3), 579-589. doi:10.1007/s10334-016-0524-9.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-79B2-F Version Permalink: http://hdl.handle.net/21.11116/0000-0000-79B3-E
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
Link (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Mirkes, C1, Author              
Shajan, G1, Author              
Chadzynski, G1, Author              
Buckenmaier, K1, 2, Author              
Bender, B, Author
Scheffler, K1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Objective Investigation of the feasibility and performance of phosphorus (31P) magnetic resonance spectroscopic imaging (MRSI) at 9.4 T with a three-layered phosphorus/proton coil in human normal brain tissue and tumor. Materials and methods A multi-channel 31P coil was designed to enable MRSI of the entire human brain. The performance of the coil was evaluated by means of electromagnetic field simulations and actual measurements. A 3D chemical shift imaging approach with a variable repetition time and flip angle was used to increase the achievable signal-to-noise ratio of the acquired 31P spectra. The impact of the resulting k-space modulation was investigated by simulations. Three tumor patients and three healthy volunteers were scanned and differences between spectra from healthy and cancerous tissue were evaluated qualitatively. Results The high sensitivity provided by the 27-channel 31P coil allowed acquiring CSI data in 22 min with a nominal voxel size of 15 × 15 × 15 mm3. Shimming and anatomical localization could be performed with the integrated four-channel proton dipole array. The amplitudes of the phosphodiesters and phosphoethanolamine appeared reduced in tumorous tissue for all three patients. A neutral or slightly alkaline pH was measured within the brain lesions. Conclusion These initial results demonstrate that 31P 3D CSI is feasible at 9.4 T and could be performed successfully in healthy subjects and tumor patients in under 30 min.

Details

show
hide
Language(s):
 Dates: 2016-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1007/s10334-016-0524-9
BibTex Citekey: MirkesSCBBS2016
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Magnetic Resonance Materials in Physics, Biology and Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 29 (3) Sequence Number: - Start / End Page: 579 - 589 Identifier: -