English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Ratiometric Method for Rapid Monitoring of Biological Processes Using Bioresponsive MRI Contrast Agents

Gündüz, S., Savić, T., Pohmann, R., Logothetis, N., Scheffler, K., & Angelovski, G. (2016). Ratiometric Method for Rapid Monitoring of Biological Processes Using Bioresponsive MRI Contrast Agents. ACS Sensors, 1(5), 483-487. doi:10.1021/acssensors.6b00011.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-79C2-D Version Permalink: http://hdl.handle.net/21.11116/0000-0000-FA3D-3
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
Link (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Gündüz, S1, 2, Author              
Savić, T1, 2, Author              
Pohmann, R1, 3, Author              
Logothetis, NK1, 4, Author              
Scheffler, K1, 3, Author              
Angelovski, G1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
4Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

Content

show
hide
Free keywords: -
 Abstract: Bioresponsive MRI contrast agents hold great potential for non-invasive tracking of essential biological processes. Consequently, a number of MR sensors for several imaging protocols have been developed, attempting to produce the maximal signal difference for a given event. Here we introduce an approach which could substantially improve the detection of physiological events with fast kinetics. We developed a nanosized, calcium-sensitive dendrimeric probe that changes longitudinal and transverse relaxation times with different magnitudes. The change in their ratio is rapidly recorded by means of a balanced steady-state free precession (bSSFP) imaging protocol. The employed methodology results in an almost four times greater signal gain per unit of time as compared to conventional T1-weighted imaging with small sized contrast agents. Furthermore, it is suitable for high resolution functional MRI at high magnetic fields. This methodology could evolve into a valuable tool for rapid monitoring of various biological events.

Details

show
hide
Language(s):
 Dates: 2016-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1021/acssensors.6b00011
BibTex Citekey: GunduzSPLSA2016
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: ACS Sensors
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 1 (5) Sequence Number: - Start / End Page: 483 - 487 Identifier: -