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  17O relaxation times in the rat brain at 16.4 tesla

Wiesner, H., Balla, D., Shajan, G., Scheffler, K., Ugurbil, K., Chen, W., et al. (2016). 17O relaxation times in the rat brain at 16.4 tesla. Magnetic Resonance in Medicine, 75(5), 1886-1893. doi:10.1002/mrm.25814.

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Wiesner, HM1, Autor           
Balla, DZ1, 2, 3, Autor           
Shajan, G1, 2, Autor           
Scheffler, K1, 2, Autor           
Ugurbil, K, Autor
Chen, W, Autor
Uludag, K1, 2, Autor           
Pohmann, R1, 2, Autor           
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Zusammenfassung: Purpose
Measurement of the cerebral metabolic rate of oxygen (CMRO2) by means of direct imaging of the 17O signal can be a valuable tool in neuroscientific research. However, knowledge of the longitudinal and transverse relaxation times of different brain tissue types is required, which is difficult to obtain because of the low sensitivity of natural abundance H217O measurements.
Methods
Using the improved sensitivity at a field strength of 16.4 Tesla, relaxation time measurements in the rat brain were performed in vivo and postmortem with relatively high spatial resolutions, using a chemical shift imaging sequence.
Results
In vivo relaxation times of rat brain were found to be T1 = 6.84 ± 0.67 ms and T2* = 1.77 ± 0.04 ms. Postmortem H217O relaxometry at enriched concentrations after inhalation of 17O2 showed similar T2* values for gray matter (1.87 ± 0.04 ms) and white matter, significantly longer than muscle (1.27 ± 0.05 ms) and shorter than cerebrospinal fluid (2.30 ± 0.16 ms).
Conclusion
Relaxation times of brain H217O were measured for the first time in vivo in different types of tissues with high spatial resolution. Because the relaxation times of H217O are expected to be independent of field strength, our results should help in optimizing the acquisition parameters for experiments also at other MRI field strengths.

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 Datum: 2016-05
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1002/mrm.25814
BibTex Citekey: WiesnerBSSUCUP2015
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Titel: Magnetic Resonance in Medicine
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York : Wiley-Liss
Seiten: - Band / Heft: 75 (5) Artikelnummer: - Start- / Endseite: 1886 - 1893 Identifikator: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149