English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Ketamine administration reduces amygdalo-hippocampal reactivity to emotional stimulation

Scheidegger, M., Henning, A., Walter, M., Lehmann, M., Kraehenmann, R., Boeker, H., et al. (2016). Ketamine administration reduces amygdalo-hippocampal reactivity to emotional stimulation. Human Brain Mapping, 37(5), 1941-1952. doi:10.1002/hbm.23148.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-79D0-D Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1F05-8
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
Link (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Scheidegger, M, Author
Henning, A1, 2, Author              
Walter, M, Author              
Lehmann, M, Author
Kraehenmann, R, Author
Boeker, H, Author
Seifritz, E, Author
Grimm, S, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              

Content

show
hide
Free keywords: -
 Abstract: Increased amygdala reactivity might lead to negative bias during emotional processing that can be reversed by antidepressant drug treatment. However, little is known on how N-methyl-d-aspartate (NMDA) receptor antagonism with ketamine as a novel antidepressant drug target might modulate amygdala reactivity to emotional stimulation. Using functional magnetic resonance imaging (fMRI) and resting-state fMRI (rsfMRI), we assessed amygdalo-hippocampal reactivity at baseline and during pharmacological stimulation with ketamine (intravenous bolus of 0.12 mg/kg, followed by a continuous infusion of 0.25 mg/kg/h) in 23 healthy subjects that were presented with stimuli from the International Affective Picture System (IAPS). We found that ketamine reduced neural reactivity in the bilateral amygdalo-hippocampal complex during emotional stimulation. Reduced amygdala reactivity to negative pictures was correlated to resting-state connectivity to the pregenual anterior cingulate cortex. Interestingly, subjects experienced intensity of psychedelic alterations of consciousness during ketamine infusion predicted the reduction in neural responsivity to negative but not to positive or neutral stimuli. Our findings suggest that the pharmacological modulation of glutamate-responsive cerebral circuits, which is associated with a shift in emotional bias and a reduction of amygdalo-hippocampal reactivity to emotional stimuli, represents an early biomechanism to restore parts of the disrupted neurobehavioral homeostasis in MDD patients.

Details

show
hide
Language(s):
 Dates: 2016-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/hbm.23148
BibTex Citekey: ScheideggerHWLKBSG2016
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Human Brain Mapping
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 37 (5) Sequence Number: - Start / End Page: 1941 - 1952 Identifier: -