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  Ripple-triggered stimulation of the locus coeruleus during post-learning sleep disrupts ripple/spindle coupling and impairs memory consolidation

Novitskaya, Y., Sara, S., Logothetis, N., & Eschenko, O. (2016). Ripple-triggered stimulation of the locus coeruleus during post-learning sleep disrupts ripple/spindle coupling and impairs memory consolidation. Learning Memory, 23(5), 238-248. doi:10.1101/lm.040923.115.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-79D4-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-79D5-8
Genre: Journal Article

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Novitskaya, Y1, Author              
Sara, SJ, Author
Logothetis, NK1, 2, Author              
Eschenko, O1, 2, Author              
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1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Experience-induced replay of neuronal ensembles occurs during hippocampal high-frequency oscillations, or ripples. Post-learning increase in ripple rate is predictive of memory recall, while ripple disruption impairs learning. Ripples may thus present a fundamental component of a neurophysiological mechanism of memory consolidation. In addition to system-level local and cross-regional interactions, a consolidation mechanism involves stabilization of memory representations at the synaptic level. Synaptic plasticity within experience-activated neuronal networks is facilitated by noradrenaline release from the axon terminals of the locus coeruleus (LC). Here, to better understand interactions between the system and synaptic mechanisms underlying “off-line” consolidation, we examined the effects of ripple-associated LC activation on hippocampal and cortical activity and on spatial memory. Rats were trained on a radial maze; after each daily learning session neural activity was monitored for 1 h via implanted electrode arrays. Immediately following “on-line” detection of ripple, a brief train of electrical pulses (0.05 mA) was applied to LC. Low-frequency (20 Hz) stimulation had no effect on spatial learning, while higher-frequency (100 Hz) trains transiently blocked generation of ripple-associated cortical spindles and caused a reference memory deficit. Suppression of synchronous ripple/spindle events appears to interfere with hippocampal-cortical communication, thereby reducing the efficiency of “off-line” memory consolidation.

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 Dates: 2016-05
 Publication Status: Published in print
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 Identifiers: DOI: 10.1101/lm.040923.115
BibTex Citekey: NovitskayaSLE2016
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Title: Learning Memory
Source Genre: Journal
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Pages: - Volume / Issue: 23 (5) Sequence Number: - Start / End Page: 238 - 248 Identifier: -