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  Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex

Klein, C., Evrard, H., Shapcott, K., Haverkamp, S., Logothetis, N., & Schmid, M. (2016). Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex. Neuron, 90(1), 143-151. doi:10.1016/j.neuron.2016.02.036.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-79E0-B Version Permalink: http://hdl.handle.net/21.11116/0000-0000-79E1-A
Genre: Journal Article

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Klein, C1, 2, Author              
Evrard, HC1, 2, 3, Author              
Shapcott, KA, Author
Haverkamp, S, Author
Logothetis, NK1, 2, Author              
Schmid, MC2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
3Dept. Empirical Inference, Max Planck Institute for Intelligent System, Max Planck Society, ou_1497647              

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 Abstract: Electrical microstimulation and more recently optogenetics are widely used to map large-scale brain circuits. However, the neuronal specificity achieved with both methods is not well understood. Here we compare cell-targeted optogenetics and electrical microstimulation in the macaque monkey brain to functionally map the koniocellular lateral geniculate nucleus (LGN) projection to primary visual cortex (V1). Selective activation of the LGN konio neurons with CamK-specific optogenetics caused selective electrical current inflow in the supra-granular layers of V1. Electrical microstimulation targeted at LGN konio layers revealed the same supra-granular V1 activation pattern as the one elicited by optogenetics. Taken together, these findings establish a selective koniocellular LGN influence on V1 supra-granular layers, and they indicate comparable capacities of both stimulation methods to isolate thalamo-cortical circuits in the primate brain.

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 Dates: 2016-04
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.neuron.2016.02.036
BibTex Citekey: KleinESHLS2016
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Title: Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 90 (1) Sequence Number: - Start / End Page: 143 - 151 Identifier: -