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  Sensory and optogenetically driven single-vessel fMRI

Yu, X., He, Y., Wang, M., Merkle, H., Dodd, S., Silva, A., et al. (2016). Sensory and optogenetically driven single-vessel fMRI. Nature methods, 13(4), 337-340. doi:10.1038/nmeth.3765.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-79F4-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-6EB9-1
Genre: Journal Article

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Yu, X1, 2, Author              
He, Y1, 2, Author              
Wang, M1, Author              
Merkle, H2, 3, Author              
Dodd, SJ, Author
Silva, AC, Author
Koretsky, AP, Author
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Magnetic resonance imaging (MRI) sensitivity approaches vessel specificity. We developed a single-vessel functional MRI (fMRI) method to image the contribution of vascular components to blood oxygenation level–dependent (BOLD) and cerebral blood volume (CBV) fMRI signal. We mapped individual vessels penetrating the rat somatosensory cortex with 100-ms temporal resolution by MRI with sensory or optogenetic stimulation. The BOLD signal originated primarily from venules, and the CBV signal from arterioles. The single-vessel fMRI method and its combination with optogenetics provide a platform for mapping the hemodynamic signal through the neurovascular network with specificity at the level of individual arterioles and venules.

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 Dates: 2016-04
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1038/nmeth.3765
BibTex Citekey: Yu2016
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Title: Nature methods
  Other : Nature methods
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 13 (4) Sequence Number: - Start / End Page: 337 - 340 Identifier: ISSN: 1548-7091
CoNE: https://pure.mpg.de/cone/journals/resource/111088195279556