Sensory and optogenetically driven single-vessel fMRI

Yu, X; He, Y; Wang, M; Merkle, H; Dodd, SJ; Silva, AC; Koretsky, AP

doi:10.1038/nmeth.3765

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Sensory and optogenetically driven single-vessel fMRI

Yu, X., He, Y., Wang, M., Merkle, H., Dodd, S., Silva, A., et al. (2016). Sensory and optogenetically driven single-vessel fMRI. Nature Methods, 13(4), 337-340. doi:10.1038/nmeth.3765.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-79F4-5 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-FAE8-1

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Yu, X^{1, 2}, Author
He, Y^{1, 2}, Author
Wang, M¹, Author
Merkle, H^{2, 3}, Author
Dodd, SJ, Author
Silva, AC, Author
Koretsky, AP, Author

Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796

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Abstract: Magnetic resonance imaging (MRI) sensitivity approaches vessel specificity. We developed a single-vessel functional MRI (fMRI) method to image the contribution of vascular components to blood oxygenation level–dependent (BOLD) and cerebral blood volume (CBV) fMRI signal. We mapped individual vessels penetrating the rat somatosensory cortex with 100-ms temporal resolution by MRI with sensory or optogenetic stimulation. The BOLD signal originated primarily from venules, and the CBV signal from arterioles. The single-vessel fMRI method and its combination with optogenetics provide a platform for mapping the hemodynamic signal through the neurovascular network with specificity at the level of individual arterioles and venules.

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Dates: Date issued: 2016-04

Publication Status: Issued

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Identifiers: DOI: 10.1038/nmeth.3765
BibTex Citekey: Yu2016

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Title: Nature Methods

Source Genre: Journal

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Pages: - Volume / Issue: 13 (4) Sequence Number: - Start / End Page: 337 - 340 Identifier: -