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  Central Nervous System Stromal Cells Control Local CD8(+) T Cell Responses during Virus-Induced Neuroinflammation

Cupovic, J., Onder, l., Gil-Cruz, C., Weiler, E., Caviezel-Firner, S., Perez-Shibayama, C., et al. (2016). Central Nervous System Stromal Cells Control Local CD8(+) T Cell Responses during Virus-Induced Neuroinflammation. Immunity, 44(3), 622-633. doi:10.1016/j.immuni.2015.12.022.

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Cupovic, J, Author
Onder, l, Author
Gil-Cruz, C, Author
Weiler, E1, 2, Author              
Caviezel-Firner, S, Author
Perez-Shibayama, C, Author
Rülicke, T, Author
Bechmann, I, Author
Ludewig, B, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Stromal cells generate a complex cellular scaffold that provides specialized microenvironments for lymphocyte activation in secondary lymphoid organs. Here, we assessed whether local activation of stromal cells in the central nervous system (CNS) is mandatory to transfer immune recognition from secondary lymphoid organs into the infected tissue. We report that neurotropic virus infection in mice triggered the establishment of such stromal cell niches in the CNS. CNS stromal cell activation was dominated by a rapid and vigorous production of CC-motif chemokine receptor (CCR) 7 ligands CCL19 and CCL21 by vascular endothelial cells and adjacent fibroblastic reticular cell (FRC)-like cells in the perivascular space. Moreover, CCR7 ligands produced by CNS stromal cells were crucial to support recruitment and local re-activation of antiviral CD8+ T cells and to protect the host from lethal neuroinflammatory disease, indicating that CNS stromal cells generate confined microenvironments that control protective T cell immunity.

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 Dates: 2016-03
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.immuni.2015.12.022
BibTex Citekey: CupovicOGWCPRBL2016
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Title: Immunity
Source Genre: Journal
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Pages: - Volume / Issue: 44 (3) Sequence Number: - Start / End Page: 622 - 633 Identifier: -