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  Quantitative and functional pulsed arterial spin labeling in the human brain at 9.4 t

Bause, J., Ehses, P., Mirkes, C., Shajan, G., Scheffler, K., & Pohmann, R. (2016). Quantitative and functional pulsed arterial spin labeling in the human brain at 9.4 t. Magnetic Resonance in Medicine, 75(3), 1054-1063. doi:10.1002/mrm.25671.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7A0A-D Version Permalink: http://hdl.handle.net/21.11116/0000-0000-FA38-8
Genre: Journal Article

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Bause, J1, 2, Author              
Ehses, P2, Author              
Mirkes, C2, Author              
Shajan, G2, Author              
Scheffler, K1, 2, Author              
Pohmann, R1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Purpose The feasibility of multislice pulsed arterial spin labeling (PASL) of the human brain at 9.4 T was investigated. To demonstrate the potential of arterial spin labeling (ASL) at this field strength, quantitative, functional, and high-resolution (1.05 × 1.05 × 2 mm3) ASL experiments were performed. Methods PASL was implemented using a numerically optimized adiabatic inversion pulse and presaturation scheme. Quantitative measurements were performed at 3 T and 9.4 T and evaluated on a voxel-by-voxel basis. In a functional experiment, activation maps obtained with a conventional blood-oxygen-level-dependent (BOLD)-weighted sequence were compared with a functional ASL (fASL) measurement. Results Quantitative measurements revealed a 23 lower perfusion in gray matter and 17 lower perfusion in white matter at 9.4 T compared with 3 T. Furthermore almost identical transit delays and bolus durations were found at both field strengths whereas the calculated voxel volume corrected signal-to-noise ratio was 1.9 times higher at 9.4 T. This result was confirmed by the high-resolution experiment. The functional experiment yielded comparable activation maps for the fASL and BOLD measurements. Conclusion Although PASL at ultrahigh field strengths is limited by high specific absorption rate, functional and quantitative perfusion-weighted images showing a high degree of detail can be obtained.

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 Dates: 2016-03
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.25671
BibTex Citekey: BauseEMSSP2015
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 75 (3) Sequence Number: - Start / End Page: 1054 - 1063 Identifier: -