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  Glutamatergic and neurometabolic alterations in chronic cocaine users measured with 1H-magnetic resonance spectroscopy

Hulka, L., Scheidegger, M., Vonmoos, M., Preller, K., Baumgartner, M., Herdener, M., et al. (2016). Glutamatergic and neurometabolic alterations in chronic cocaine users measured with 1H-magnetic resonance spectroscopy. Addiction Biology, 21(1), 205-217. doi:10.1111/adb.12217.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7A42-D Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1E05-9
Genre: Journal Article

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Hulka, LM, Author
Scheidegger, M, Author
Vonmoos, M, Author
Preller, KH, Author
Baumgartner, MR, Author
Herdener, M, Author              
Seifritz, E, Author
Henning, A1, 2, Author              
Quednow, BB, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528692              

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 Abstract: Cocaine addiction is a chronically relapsing disorder that is associated with harmful consequences. Relapses occur frequently and effective pharmacotherapies are currently sparse. Preclinical studies suggest that altered glutamatergic signaling is crucial for the maintenance of cocaine self-administration. However, the translational validity of these models is currently unknown. Therefore, we investigated potential differences of glutamate, glutamine and further metabolite levels in the pregenual anterior cingulate cortex (pgACC) and the right dorsolateral prefrontal cortex (rDLPFC) of chronic cocaine users and controls using the PRior knOwledge FITting 2.0 tool in combination with two-dimensional J-resolved single-voxel 1H-magnetic resonance spectroscopy at 3T and voxel tissue composition and relaxation correction. Glutamate and glutamine levels did not differ between cocaine users and controls, but higher weekly cocaine use and higher cocaine hair concentrations were associated with lower glutamine/creatine ratios in the pgACC. Interestingly, cocaine users exhibited higher glucose/total creatine ratios than controls in the pgACC and higher choline/creatine ratios in the pgACC and rDLPFC. These results imply that cocaine use is associated with altered cortical glucose metabolism and membrane turnover. Finally, cocaine use over the past 6 months appears to decrease cortical glutamine levels indicating changes in glutamate cycling.

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 Dates: 2015-122016-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1111/adb.12217
BibTex Citekey: HulkaSVPBHSHQ2014
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Title: Addiction Biology
Source Genre: Journal
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Pages: - Volume / Issue: 21 (1) Sequence Number: - Start / End Page: 205 - 217 Identifier: -