English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  A 9.4T human fMRI study reveals differential laminar responses for visual motion in eye- and world-centered reference frames in area V3A

Molaei-Vaneghi, F., Scheffler, K., & Bartels, A. (2016). A 9.4T human fMRI study reveals differential laminar responses for visual motion in eye- and world-centered reference frames in area V3A. Poster presented at 46th Annual Meeting of the Society for Neuroscience (Neuroscience 2016), San Diego, CA, USA.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7ADC-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-F341-4
Genre: Poster

Files

show Files

Locators

show
hide
Locator:
Link (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Molaei-Vaneghi, F1, 2, Author              
Scheffler, K1, 2, Author              
Bartels, A1, 3, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

Content

show
hide
Free keywords: -
 Abstract: Neural mechanisms underlying a stable perception of the world during pursuit eye movements are not fully understood. Both, perceptual stability as well as perception of real-world motion are the product of multi-modal integration between retinal motion (visual motion signals) and efference copies of eye movements (non-visual motion signals). The comparison between these two signals allows differentiating between self-induced motion and external, real-world motion. Recently, pursuit-paradigms revealed that human area V3A responds to motion predominantly in a world-centered rather than in a retina-centered reference frame (Fischer et al., 2012). This indicates that V3A integrates retinal motion with non-retinal eye-movement signals. In this study we combined ultra-high-field (9.4T) human fMRI, state of the art pulse sequences, and laminar analysis to find out if there is a differential involvement of cortical layers in the processing of real world motion compared to retinal motion in area V3A. We used a 2D GE EPI sequence with 0.8 mm isotropic resolution to measure BOLD signal at different cortical depths while subjects performed a visual pursuit task. The paradigm involved a 2x2 design containing real motion and visual pursuit, which allowed separating responses to retinal and real motion while fully controlling for pursuit-related effects. A laminar surface-based analysis method was used to study the relationship between spatial localization and activation strength as a function of cortical depth by sampling the BOLD signal from the superficial, middle, or deep cortical lamina in area V3A. The results show that signals related to retinal motion were evenly spread across layers with a bias towards deep layers of V3A while real-motion responses had a gradient with a peak in superficial layers. The differential laminar response profile is compatible with differential local processing for the two motion types. The stronger involvement of superficial layers during real motion processing may be indicative of feedback related processing, possibly through mediation of efference-copy related signals from higher-level regions such as parietal cortex or smooth pursuit fields of the frontal eye fields with which V3A has direct connections. Future studies are needed to clarify the reasons for differential laminar responses and to identify communication pathways leading to V3A.

Details

show
hide
Language(s):
 Dates: 2016-11-14
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: BibTex Citekey: MolaeiVaneghiSB2016
 Degree: -

Event

show
hide
Title: 46th Annual Meeting of the Society for Neuroscience (Neuroscience 2016)
Place of Event: San Diego, CA, USA
Start-/End Date: -

Legal Case

show

Project information

show

Source 1

show
hide
Title: 46th Annual Meeting of the Society for Neuroscience (Neuroscience 2016)
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: 328.06 Start / End Page: - Identifier: -