English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Novel insights into neurometabolic mechanisms of cocaine addiction: Reduced glutamate levels in the nucleus accumbens

Engeli, E., Hock, A., Zoelch, N., Hulka, L., Kirschner, M., Stämpfli, P., et al. (2016). Novel insights into neurometabolic mechanisms of cocaine addiction: Reduced glutamate levels in the nucleus accumbens. Poster presented at 3rd Burghölzli Psychiatry Meeting (BPM 2016), Zürich, Switzerland.

Item is

Files

show Files

Locators

show
hide
Locator:
Link (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Engeli, EJE, Author
Hock, A, Author
Zoelch, N, Author
Hulka, LM, Author
Kirschner, M, Author
Stämpfli, P, Author
Henning, A1, 2, Author              
Seifritz, E, Author
Quednow, BB, Author
Herdener, M, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              

Content

show
hide
Free keywords: -
 Abstract: Introduction Animal studies show that chronic cocaine use leads to decreased glutamate levels in the nucleus accumbens (NAcc), whereas drug‐seeking reinstatement is accompanied by enhanced glutamatergic transmission 1. However, little is known about such neurometabolic alterations in humans. We thus aim to investigate changes of the glutamate homeostasis in the NAcc of cocaine dependent individuals by means of a novel proton magnetic resonance spectroscopy (1H‐MRS) protocol that we have recently developed. Methods In 16 cocaine dependent individuals (CD) and 22 healthy controls (HC), non‐water suppressed PRESS localization 1H‐MRS preceded by a metabolite‐cycling pulse combined with inner‐volume saturation was performed on a 3T Philips Achieva System. MRS spectra were obtained from a voxel of 9.4x18.8x8.4mm, covering the anatomical dimensions of the left NAcc. For absolute quantification of the metabolites, a method based on the principle of reciprocity has been applied. Results An average signal‐to‐noise ratio of 16.97 and a mean line width of 6.93Hz (in single spectra) indicate good spectral quality. Metabolite concentrations of interest were quantified reliably using LCModel4 with Cramér‐Rao lower bounds<10. Moreover, glutamate concentrations in CDs (M=0.011, SD=0.001) were significantly reduced compared to HCs (M=0.013, SD=0.002), t(34)=3.81, p=.001, d=1.20. Discussion Despite the small voxel size, this novel 1H‐MRS protocol achieves high data quality and, thus, finally allows a reliable detection of glutamate in the human NAcc. For the first time this reveals that, in accordance with animal models, glutamatergic alterations occur in cocaine dependent humans and might play a decisive role in the development and maintenance of cocaine dependence.

Details

show
hide
Language(s):
 Dates: 2016-10-25
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: BibTex Citekey: EngeliHZHKSHSQH2016
 Degree: -

Event

show
hide
Title: 3rd Burghölzli Psychiatry Meeting (BPM 2016)
Place of Event: Zürich, Switzerland
Start-/End Date: -

Legal Case

show

Project information

show

Source 1

show
hide
Title: 3rd Burghölzli Psychiatry Meeting (BPM 2016)
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 23 - 23 Identifier: -