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  A Ratiometric Bioresponsive MRI Contrast Agent for Rapid Monitoring of Biological Processes

Savić, T., Gündüz, S., Pohmann, R., Logothetis, N., Scheffler, K., & Angelovski, G. (2016). A Ratiometric Bioresponsive MRI Contrast Agent for Rapid Monitoring of Biological Processes. Poster presented at 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7B90-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-FA18-C
Genre: Poster

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 Creators:
Savić, T1, 2, Author              
Gündüz, S1, 2, Author              
Pohmann, R1, 3, Author              
Logothetis, NK1, 4, Author              
Scheffler, K1, 3, Author              
Angelovski, G1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
4Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: A number of bioresponsive MRI contrast agents have been developed, with the aim of producing the maximal signal difference for a given biological event. This paper introduces an approach which substantially improves the detection of physiological events with fast kinetics. A nanosized, calcium-sensitive dendrimeric probe was developed and characterized by means of a balanced steady-state free precession imaging protocol. Results show an almost four times greater contrast gain per unit of time as compared to conventional T1-weighted imaging with small sized contrast agents. Consequently, this ratiometric methodology has a profound significance for future studies of biological dynamic processes by means of MRI.

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 Dates: 2016-05-11
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: SavicGPLSA2016
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Title: 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016)
Place of Event: Singapore
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Title: 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 2307 Start / End Page: - Identifier: -