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  In-vivo ultra-high resolution structural imaging of the human superior colliculus at 9.4T: validation with ex vivo measurements at 9.4T and 14T

Loureiro, J., Hagberg, G., Tuzzi, E., Himmelbach, M., Ethofer, T., Grodd, W., et al. (2016). In-vivo ultra-high resolution structural imaging of the human superior colliculus at 9.4T: validation with ex vivo measurements at 9.4T and 14T. Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1), S376-S377.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7C24-D Version Permalink: http://hdl.handle.net/21.11116/0000-0000-FA2A-8
Genre: Meeting Abstract

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Loureiro, J1, Author              
Hagberg, G1, 2, Author              
Tuzzi, E1, 2, Author              
Himmelbach, M, Author
Ethofer, T, Author
Grodd, W1, 2, Author              
Martin, P, Author
Valverde, M1, 3, Author              
Pohmann, R1, 2, Author              
Scheffler, K1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Purpose/Introduction: The Superior Colliculus is a paired layered structure that regulates eye and head movements and is involved in multisensory control. It is divided in 7 alternating fibrous and cellular layers and our goal is to find methods capable of improving the contrast in the SC and separating its layers in vivo. In this study the visibility of the SC in vivo at 9.4T was investigated and validated with ex vivo measurements at 9.4T and 14T. Subjects and Methods: For the in vivo measurements 10 subjects were measured at the 9.4T Siemens, Erlangen. For each participant three different sequences were used: acquisition-weighted (AW) [1] (nominal resolution of 0.175 9 0.132 9 0.6; TE = 18 ms), multiecho (ME) 3D GRE (0.4 mm isotropic resolution, TE = 6:6:36 ms), and whole brain MP2RAGE (0.8 isotropic resolution). The AW images were k-space filtered with a Hanning function in the phase encoding dimension [2] in order to increase the SNR. R2* maps were calculated from the ME images [3]. VOIs of the SC were drawn based on the AW images and the R2* maps in the coordinate space of the AW images for each subject and both hemispheres. The contrast-tonoise-ratio (CNR) between the SC and a WM VOI was calculated. The post-mortem brainstem sample was fixed in formalin (4 ), measured in the 9.4T using the in vivo protocol, and then cut to fit the 14T volume coil. At 14T, 3D GRE (50 lm isotropic resolution) and DTI EPI (6dir, b = 10,000, 300 lm isotropic resolution). Results: In-vivo the AW sequence yielded the highest CNR values in the SC. The quantitative R2*map did not improve the CNR and higher values were obtained for the 5thecho of the ME sequence (36 ms). CNR was very low for the MP2RAGE sequence (Fig. 1). The GRE ex vivo images were comparable to the in vivo images. The first eigenvector of the DTI images show the superficial layer in accordance to its anatomy and also a layering structure in the middle part of the SC, which may represent one of the intermediate layers of the SC. Structural details that are not visible in vivo were revealed with the ex vivo scans (Fig. 2). Discussion/Conclusion: This experiment emphasizes the potential of UHF MRI in measuring deep-bain structures. The use of 9.4T in vivo and the comparison of this data with ex vivo samples may enable us to create more robust and accurate atlases of the SC and possibly reveal the layering pattern of the SC.

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 Dates: 2016-10-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1007/s10334-016-0570-3
BibTex Citekey: LoureiroHTHEGMVPS2016
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Title: 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016)
Place of Event: Wien, Austria
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Title: Magnetic Resonance Materials in Physics, Biology and Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 29 (Supplement 1) Sequence Number: - Start / End Page: S376 - S377 Identifier: -