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  Dense Statistical Connectome of Rat Barrel Cortex

Udvary, D., Egger, R., Dercksen, V., & Oberlaender, M. (2016). Dense Statistical Connectome of Rat Barrel Cortex. In 17th Conference of Junior Neuroscientists of Tübingen (NeNa 2016): Neuroscience & Law (pp. 11-11).

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7C67-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-DDFC-C
Genre: Meeting Abstract

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Udvary, D1, 2, Author              
Egger, R1, 2, Author              
Dercksen, VJ, Author
Oberlaender, M1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Former Research Group Computational Neuroanatomy, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528698              

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 Abstract: Synaptic connectivity is one important constrain for cortical signal ow and function. Consequently, a complete synaptic connectivity map (i.e., connectome) of a cortical area across spatial scales would advance our understanding of cortex organization and function. We present a dense statistical connectome of the entire rat vibrissal cortex based on measured 3D distributions of axons/dendrites/somata of excitatory and inhibitory neurons. By calculating the structural overlap between pre- and postsynaptic cells our model provides quantitative estimates on connectivity measurements like connection probability and number of synapses on cell type, cellular, and subcellular levels. We found that our model reproduces connectivity measurements between thalamic and excitatory/inhibitory neurons reported in paired recordings and light- and electronmicroscopic studies. Similarly, intracortical synaptic connectivity of our model matches most connectivity measurements. However, the location and distance between pre- and postsynaptic cells and - in case of slicing experiments - the degree of truncation strongly in uences the connectivity. When reproducing electronmicroscopic and in vitro slicing experiments in our model, we found that measurements obtained under the respective experimental conditions are in line with our model's results, but represent only a small fraction of the underlying distribution. The experimental conditions such as the small volume analyzed in electron-microscopic studies or the truncation of morphologies thus biases the conclusions that are drawn, e.g. an underestimation of the connection probability. Our approach can therefore be used to improve experimental design and seen as a starting point to simulate sensory-evoked signal ow and investigate structural and functional organization of the cortex.

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 Dates: 2016-09
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: UdvaryEDO2017
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Title: 17th Conference of Junior Neuroscientists of Tübingen (NeNa 2016): Neuroscience & Law
Place of Event: Schramberg, Germany
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Title: 17th Conference of Junior Neuroscientists of Tübingen (NeNa 2016): Neuroscience & Law
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 11 - 11 Identifier: -