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Abstract:
Background and Aims: Oxidative stress and mitochondrial dysfunction are two closely integrated processes implicated in the physiopathology of bipolar disorder (BD). Advanced 1H-MRS techniques enable the measurement of levels of lactate (Lac), the main marker of mitochondrial dysfunction, and glutathione (GSH), the predominant brain antioxidant. The objective of this study was to measure brain Lac and GSH levels in BD and healthy controls (HC).
Methods: Eighty-eight individuals (50 BD and 38 HC) underwent 3T 1H-MRS in the supragenual anterior cingulate cortex (sACC) (2 9 2 9 4.5 cm3) using a 2-D JPRESS sequence. Lac and GSH were quantified using the ProFit software program.
Results: BD patients had higher sACC Lac levels compared to controls. GSH levels did not differ between euthymic BD and controls. There was a positive correlation between Lac and GSH levels regardless of psychiatric diagnose. No influence of medications on metabolites was observed.
Conclusions: This is the most extensive MRS study of Lac and
GSH in BD to date and results indicated that euthymic BD patients had higher levels of Lac, which might be an indication of altered mitochondrial function. Moreover, Lac levels correlated with GSH levels, indicating a compensatory mechanism regardless of BD diagnose.
