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Abstract:
Previously, we have developed a single-vessel fMRI method to visualize the hemodynamic signal propagation from individual venules and arterioles in the deep layer cortex. Here, we combined single-vessel fMRI with optogenetic photo-activation to map vessel-specific fMRI signal from the rat hippocampus. A MGE sequence was used to distinguish the individual arterioles and venules penetrating the main structure of the hippocampus. The BOLD-fMRI signal was mapped to overlap with the individual venules. This result makes it possible to study the coupled neuronal and vascular interaction in the focal hippocampal stroke rat model, which may mimic the pathophysiological basis of transient global amnesia in human.
