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  Consistent detection of age-dependent variations of the longitudinal relaxation time in cortical brain regions investigated by MP2RAGE at 9.4T: influence of correcting for a non-uniform transmit field

Hagberg, G., Bause, J., Ethofer, T., Ehses, P., Dresler, T., Shajan, G., et al. (2016). Consistent detection of age-dependent variations of the longitudinal relaxation time in cortical brain regions investigated by MP2RAGE at 9.4T: influence of correcting for a non-uniform transmit field. In 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016).

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7CE2-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-E1C8-B
Genre: Meeting Abstract

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 Creators:
Hagberg, GE1, 2, Author              
Bause, J1, 2, Author              
Ethofer, T, Author
Ehses, P1, 2, Author              
Dresler, T, Author
Shajan, G1, 2, Author              
Pohmann, R1, 2, Author              
Herbert, C, Author
Fallgatter, A, Author
Laske, C, Author
Pavlova, M, Author              
Scheffler, K1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Accurate and precise determination of T1 values is of central importance in clinical studies and for tissue segmentation based on the myeloarchitecture that transcends T1. Here we investigate whether well-described age-dependent changes can be detected by high field T1 relaxometry, and how different transmit field correction methods influence the results. We found that the intrinsic bias correction of the MP2RAGE technique is not sufficient to achieve reliable quantification of T1 at ultra high magnetic fields. But, provided that a correction for transmit field inhomogeneity is performed, T1 maps that consistently reveal age-related changes can be generated. The technique holds promise for investigation of local myeloarchitectonics for neuroscientific and clinical studies.

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 Dates: 2016-05-09
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: HagbergBEEDSPHFLPS2016
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Title: 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016)
Place of Event: Singapore
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Title: 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0059 Start / End Page: - Identifier: -