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  Isolation of TSH and LH/CG Receptor cDNAs from Human Thyroid: Regulation by Tissue Specific Splicing

Frazier, A. L., Robbins, L. S., Stork, P. J., Sprengel, R., Segaloff, D. L., & Cone, R. D. (1990). Isolation of TSH and LH/CG Receptor cDNAs from Human Thyroid: Regulation by Tissue Specific Splicing. Molecular Endocrinology, 4(8), 1264-1276. doi:10.1210/mend-4-8-1264.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-7844-D Version Permalink: https://hdl.handle.net/21.11116/0000-0000-7845-C
Genre: Journal Article

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https://academic.oup.com/mend/article-pdf/4/8/1264/10490387/mend1264.pdf (Any fulltext)
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 Creators:
Frazier, A. Lindsay, Author
Robbins, Linda S., Author
Stork, Philip J., Author
Sprengel, Rolf1, 2, 3, Author           
Segaloff, Deborah L., Author
Cone, Roger D., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Rolf Sprengel Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497741              
3Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society, ou_1497733              

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 Abstract: A TSH receptor (TSH-R) cDNA has been isolated from a human thyroid lambda GT11 library. Unexpectedly, several cDNAs encoding the human LH/CG receptor (LH/CG-R), previously thought to be expressed solely in gonadal cells, were also isolated from the thyroid library. The receptors are structurally related, consisting of a signal sequence, a large extracellular amino terminal domain, seven membrane spanning domains, and a short carboxyl-terminal portion. The TSH-R is encoded by a single 4.2 kilobase mRNA specific to the thyroid. Introns were not present in any hTSH-R cDNAs examined, however, sequencing of several LH/CG-R cDNAs and RNase protection experiments demonstrated that the majority of hLH/CG-R mRNA in the thyroid is incompletely spliced. Consequently, tissue-specific splicing may be an important step in the regulation of the glycoprotein hormone receptor family.

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Language(s): eng - English
 Dates: 1990-04-291990-03-121990-05-071990-08-01
 Publication Status: Issued
 Pages: 13
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1210/mend-4-8-1264
URI: https://www.ncbi.nlm.nih.gov/pubmed/2293030
URI: https://www.ncbi.nlm.nih.gov/m/pubmed/2293030/
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Title: Molecular Endocrinology
Source Genre: Journal
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Publ. Info: Baltimore, MD : Endocrine Society
Pages: - Volume / Issue: 4 (8) Sequence Number: - Start / End Page: 1264 - 1276 Identifier: ISSN: 0888-8809
CoNE: https://pure.mpg.de/cone/journals/resource/954925555416