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  Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway

Holze, C., Michaudel, C., Mackowiak, C., Haas, D. A., Benda, C., Hubel, P., et al. (2017). Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. Nature Immunology. doi:10.1038/s41590-017-0013-y.

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Datensatz-Permalink: http://hdl.handle.net/21.11116/0000-0000-7DF4-1 Versions-Permalink: http://hdl.handle.net/21.11116/0000-0000-7DF5-0
Genre: Zeitschriftenartikel

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Urheber

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 Urheber:
Holze, Cathleen1, Autor              
Michaudel, Chloé2, Autor
Mackowiak, Claire2, Autor
Haas, Darya A.1, Autor              
Benda, Christian3, Autor              
Hubel, Philipp1, Autor              
Pennemann, Friederike L.1, Autor              
Schnepf, Daniel 2, Autor
Wettmarshausen, Jennifer2, Autor
Braun, Marianne4, Autor              
Leung, Daisy W. 2, Autor
Amarasinghe, Gaya K. 2, Autor
Perocchi, Fabiana2, Autor
Staeheli, Peter 2, Autor
Ryffel, Bernhard 2, Autor
Pichlmair, Andreas1, Autor              
Affiliations:
1Pichlmair, Andreas / Innate Immunity, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565166              
2External Organizations, ou_persistent22              
3Conti, Elena / Structural Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565144              
4Department: Systems and Computational Neurobiology / Borst, MPI of Neurobiology, Max Planck Society, ou_1113548              

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 Zusammenfassung: Reactive oxygen species (ROS) are generated by virus-infected cells; however, the physiological importance of ROS generated under these conditions is unclear. Here we found that the inflammation and cell death induced by exposure of mice or cells to sources of ROS were not altered in the absence of canonical ROS-sensing pathways or known cell-death pathways. ROS-induced cell-death signaling involved interactions among the cellular ROS sensor and antioxidant factor KEAP1, the phosphatase PGAM5 and the proapoptotic factor AIFM1. Pgam5–/– mice showed exacerbated lung inflammation and proinflammatory cytokines in an ozone-exposure model. Similarly, challenge with influenza A virus led to increased infiltration of the virus, lymphocytic bronchiolitis and reduced survival of Pgam5–/– mice. This pathway, which we have called ‘oxeiptosis’, was a ROS-sensitive, caspase independent, non-inflammatory cell-death pathway and was important for protection against inflammation induced by ROS or ROS-generating agents such as viral pathogens.

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 Datum: 2017-12-18
 Publikationsstatus: Online publiziert
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1038/s41590-017-0013-y
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Projektname : European Research Council (starting grant ERC-StG iVIP, 311339) German research foundation (PI 1084/2 and TRR179 to A.P.)
Grant ID : 311339
Förderprogramm : ERC-StG iVIP
Förderorganisation : European Research Council

Quelle 1

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Titel: Nature Immunology
  Andere : Nat. Immunol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : Nature America Inc.
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: - Identifikator: ISSN: 1529-2908
CoNE: /journals/resource/974392607073