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  APOE e4-genotype and lifestyle interaction on cognitive performance: Results of the LIFE-adult-study

Rodriguez, F. S., Schroeter, M. L., Arélin, K., Witte, V., Baber, R., Burkhardt, R., et al. (2018). APOE e4-genotype and lifestyle interaction on cognitive performance: Results of the LIFE-adult-study. Health Psychology, 37(2), 194-205. doi:10.1037/hea0000515.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7FCB-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A475-0
Genre: Journal Article

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 Creators:
Rodriguez, Francisca S.1, 2, 3, Author
Schroeter, Matthias L.4, 5, Author              
Arélin, Katrin4, 5, Author              
Witte, Veronica4, 5, Author              
Baber, Ronny3, 6, Author
Burkhardt, Ralph3, 6, Author
Engel, Christoph3, 7, Author
Löffler, Markus3, 7, Author
Thiery, Joachim6, Author
Villringer, Arno4, 5, Author              
Luck, Tobias2, 3, Author
Riedel-Heller, Steffi G.2, Author
Affiliations:
1Edward R. Roybal Institute on Aging, University of Southern California, Los Angeles, CA, USA, ou_persistent22              
2Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
7Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              

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Free keywords: Aging; APOE; Cognition; Gene-environment interaction; Lifestyle
 Abstract: Objective: Previous studies have shown that the e4-allele of the APOE gene is associated with a higher risk of developing dementia. Our study investigated whether well-known associations between lifestyle factors and cognitive functioning may be stronger in individuals who carry the dementia risk variant of the APOE gene and whether this association is amplified with older age. Method: Data analysis comprised 7,526 participants (aged 40- to 79-years-old) from the population-based LIFE-Adult-study. The effect of the APOE e4-allele on the association between lifestyle factors (smoking, physical activity, being overweight, occupational attainment) and cognitive performance (trail making test [TMT] B, verbal fluency test [VFT]) was analyzed via multivariate generalized linear modeling adjusted for APOE e2-allele, age, gender, education, stroke, and heart attack. Results: Smoking, less physical activity, and lower occupational attainment was associated with a poorer performance in the TMT B and VFT. Neither the APOE e4-allele nor interactions with the APOE e4-allele were significantly associated with cognitive performance. The association between physical activity and occupational attainment on performance in the TMT B were stronger in older age, but the APOE gene did not modify those associations. Conclusions: Our findings suggest that the dementia risk variant of the APOE gene does not alter the association between lifestyle factors and cognitive performance in the general population aged 40- to 79-years-old. However, as lifestyle factors impact cognitive aging, research efforts should focus on establishing effective interventions promoting healthy lifestyle behaviors to counteract adverse cognitive aging processes.

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Language(s): eng - English
 Dates: 2017-03-292016-07-072017-04-072017-12-072018-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1037/hea0000515
PMID: 29215900
Other: Epub 2017
 Degree: -

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Funding program : -
Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
Project name : -
Grant ID : -
Funding program : European Social Fund
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Free State of Saxony
Project name : -
Grant ID : 971000-084
Funding program : Junior Research Grant
Funding organization : University of Leipzig, Medical Faculty

Source 1

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Title: Health Psychology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : American Psychological Association (PsycARTICLES)
Pages: - Volume / Issue: 37 (2) Sequence Number: - Start / End Page: 194 - 205 Identifier: ISSN: 0278-6133
CoNE: /journals/resource/954925506295