English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Accelerated T2 mapping combining parallel MRI and model-based reconstruction: GRAPPATINI.

Hilbert, T., Sumpf, T., Weiland, E., Frahm, J., Thiran, J. P., Meuli, R., et al. (2018). Accelerated T2 mapping combining parallel MRI and model-based reconstruction: GRAPPATINI. Journal of Magnetic Resonance Imaging, 48(2), 359-368. doi:10.1002/jmri.25972.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-8125-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-649F-A
Genre: Journal Article

Files

show Files
hide Files
:
2548941.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
2548941.pdf
Description:
-
Visibility:
Restricted ( Max Planck Society (every institute); )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Hilbert, T., Author
Sumpf, T.1, Author              
Weiland, E., Author
Frahm, J.1, Author              
Thiran, J. P., Author
Meuli, R., Author
Kober, T., Author
Krueger, G., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

Content

show
hide
Free keywords: model‐based reconstruction; quantitative MRI; parametric mapping; T2 mapping
 Abstract: Background Quantitative T2 measurements are sensitive to intra- and extracellular water accumulation and myelin loss. Therefore, quantitative T2 promises to be a good biomarker of disease. However, T2 measurements require long acquisition times. Purpose To accelerate T2 quantification and subsequent generation of synthetic T2-weighted (T2-w) image contrast for clinical research and routine. To that end, a recently developed model-based approach for rapid T2 and M0 quantification (MARTINI) based on undersampling k-space, was extended by parallel imaging (GRAPPA) to enable high-resolution T2 mapping with access to T2-w images in less than 2 minutes acquisition time for the entire brain. Study Type Prospective cross-sectional study. Subjects/Phantom Fourteen healthy subjects and a multipurpose phantom. Field Strength/Sequence Carr–Purcell–Meiboom-Gill sequence at a 3T scanner. Assessment The accuracy and reproducibility of the accelerated T2 quantification was assessed. Validations comprised MRI studies on a phantom as well as the brain, knee, prostate, and liver from healthy volunteers. Synthetic T2-w images were generated from computed T2 and M0 maps and compared to conventional fast spin-echo (SE) images. Statistical Tests Root mean square distance (RMSD) to the reference method and region of interest analysis. Results The combination of MARTINI and GRAPPA (GRAPPATINI) lead to a 10-fold accelerated T2 mapping protocol with 1:44 minutes acquisition time and full brain coverage. The RMSD of GRAPPATINI increases less (4.3%) than a 10-fold MARTINI reconstruction (37.6%) in comparison to the reference. Reproducibility tests showed low standard deviation (SD) of T2 values in regions of interest between scan and rescan (<0.4 msec) and across subjects (<4 msec). Data Conclusion GRAPPATINI provides highly reproducible and fast whole-brain T2 maps and arbitrary synthetic T2-w images in clinically compatible acquisition times of less than 2 minutes. These abilities are expected to support more widespread clinical applications of quantitative T2 mapping. Level of Evidence: 2 Technical Efficacy: Stage 1

Details

show
hide
Language(s): eng - English
 Dates: 2018-02-152018-08-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/jmri.25972
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Magnetic Resonance Imaging
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 48 (2) Sequence Number: - Start / End Page: 359 - 368 Identifier: -