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  Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments

Talkenberger, K., Cavalcanti-Adam, E. A., Voss-Böhme, A., & Deutsch, A. (2017). Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments. Scientific Reports, 7: 9237, pp. 1-12. doi:10.1038/s41598-017-09300-3.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-816F-2 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-8170-F
Genre: Journal Article

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 Creators:
Talkenberger, Katrin, Author
Cavalcanti-Adam, Elisabetta Ada1, 2, Author           
Voss-Böhme, Anja, Author
Deutsch, Andreas, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: During tissue invasion individual tumor cells exhibit two interconvertible migration modes, namely mesenchymal and amoeboid migration. The cellular microenvironment triggers the switch between both modes, thereby allowing adaptation to dynamic conditions. It is, however, unclear if this amoeboid-mesenchymal migration plasticity contributes to a more effective tumor invasion. We address this question with a mathematical model, where the amoeboid-mesenchymal migration plasticity is regulated in response to local extracellular matrix resistance. Our numerical analysis reveals that extracellular matrix structure and presence of a chemotactic gradient are key determinants of the model behavior. Only in complex microenvironments, if the extracellular matrix is highly heterogeneous and a chemotactic gradient directs migration, the amoeboid-mesenchymal migration plasticity allows a more widespread invasion compared to the non-switching amoeboid and mesenchymal modes. Importantly, these specific conditions are characteristic for in vivo tumor invasion. Thus, our study suggests that in vitro systems aiming at unraveling the underlying molecular mechanisms of tumor invasion should take into account the complexity of the microenvironment by considering the combined effects of structural heterogeneities and chemical gradients on cell migration.

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Language(s): eng - English
 Dates: 2017-07-072017-07-252017-08-232017
 Publication Status: Issued
 Pages: 12
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41598-017-09300-3
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 7 Sequence Number: 9237 Start / End Page: 1 - 12 Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322