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  Nanoscale Control of Surface Immobilized BMP-2: Toward a Quantitative Assessment of BMP-Mediated Signaling Events

Schwab, E., Pohl, T., Haraszti, T., Schwaerzer, G. K., Hiepen, C., Spatz, J. P., et al. (2015). Nanoscale Control of Surface Immobilized BMP-2: Toward a Quantitative Assessment of BMP-Mediated Signaling Events. Nano Letters, 15(3), 1526-1534. doi: 10.1021/acs.nanolett.5b00315.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-818F-D Version Permalink: http://hdl.handle.net/21.11116/0000-0000-8190-A
Genre: Journal Article

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 Creators:
Schwab, Elisabeth1, 2, Author              
Pohl, Theresa1, 2, Author              
Haraszti, Tamas1, 2, Author              
Schwaerzer , Gerburg K., Author
Hiepen , Christian, Author
Spatz, Joachim P.1, 2, Author              
Cavalcanti-Adam, Elisabetta Ada1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: BCMN; BMP-2; cell signaling; covalent immobilization; gold nanostructures
 Abstract: In this work we determine the impact of surface density of immobilized BMP-2 on intracellular signal transduction. We use block copolymer micellar nanolithography to fabricate substrates with precisely spaced and tunable gold nanoparticle arrays carrying single BMP-2 molecules. We found that the immobilized growth factor triggers prolonged and elevated Smad signaling pathway activation compared to the same amount of soluble protein. This approach is suitable for achieving controlled and sustained local delivery of BMP-2 and other growth factors.

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Language(s): eng - English
 Dates: 2014-09-292017-02-102015
 Publication Status: Published in print
 Pages: 9
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 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Nano Letters
  Abbreviation : Nano Lett.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 15 (3) Sequence Number: - Start / End Page: 1526 - 1534 Identifier: ISSN: 1530-6984
CoNE: https://pure.mpg.de/cone/journals/resource/110978984570403