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  miRNA targeting and alternative splicing in the stress response - events hosted by membrane-less compartments.

Kucherenko, M. M., & Shcherbata, H. R. (2018). miRNA targeting and alternative splicing in the stress response - events hosted by membrane-less compartments. Journal of Cell Science, 131(4): jcs202002. doi:10.1242/jcs.202002.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-81BC-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7BE2-4
Genre: Journal Article

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2549062.pdf (Publisher version), 650KB
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 Creators:
Kucherenko, M. M.1, Author              
Shcherbata, H. R.1, Author              
Affiliations:
1Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society, ou_578608              

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Free keywords: Stress response, miRNA, Alternative splicing, RNP granule, Low-complexity sequence domain, Phase separation, Dicer, Drosha, Argonaute
 Abstract: Stress can be temporary or chronic, and mild or acute. Depending on its extent and severity, cells either alter their metabolism, and adopt a new state, or die. Fluctuations in environmental conditions occur frequently, and such stress disturbs cellular homeostasis, but in general, stresses are reversible and last only a short time. There is increasing evidence that regulation of gene expression in response to temporal stress happens post-transcriptionally in specialized subcellular membrane-less compartments called ribonucleoprotein (RNP) granules. RNP granules assemble through a concentration-dependent liquid-liquid phase separation of RNA-binding proteins that contain low-complexity sequence domains (LCDs). Interestingly, many factors that regulate microRNA (miRNA) biogenesis and alternative splicing are RNA-binding proteins that contain LCDs and localize to stress-induced liquid-like compartments. Consequently, gene silencing through miRNAs and alternative splicing of pre-mRNAs are emerging as crucial post-transcriptional mechanisms that function on a genome-wide scale to regulate the cellular stress response. In this Review, we describe the interplay between these two post-transcriptional processes that occur in liquid-like compartments as an adaptive cellular response to stress.

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Language(s): eng - English
 Dates: 2018-02-142018-02
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1242/jcs.202002
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Title: Journal of Cell Science
Source Genre: Journal
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Pages: 11 Volume / Issue: 131 (4) Sequence Number: jcs202002 Start / End Page: - Identifier: -