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  miRNA targeting and alternative splicing in the stress response - events hosted by membrane-less compartments.

Kucherenko, M. M., & Shcherbata, H. R. (2018). miRNA targeting and alternative splicing in the stress response - events hosted by membrane-less compartments. Journal of Cell Science, 131(4): jcs202002. doi:10.1242/jcs.202002.

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 Urheber:
Kucherenko, M. M.1, Autor           
Shcherbata, H. R.1, Autor           
Affiliations:
1Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society, ou_578608              

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Schlagwörter: Stress response, miRNA, Alternative splicing, RNP granule, Low-complexity sequence domain, Phase separation, Dicer, Drosha, Argonaute
 Zusammenfassung: Stress can be temporary or chronic, and mild or acute. Depending on its extent and severity, cells either alter their metabolism, and adopt a new state, or die. Fluctuations in environmental conditions occur frequently, and such stress disturbs cellular homeostasis, but in general, stresses are reversible and last only a short time. There is increasing evidence that regulation of gene expression in response to temporal stress happens post-transcriptionally in specialized subcellular membrane-less compartments called ribonucleoprotein (RNP) granules. RNP granules assemble through a concentration-dependent liquid-liquid phase separation of RNA-binding proteins that contain low-complexity sequence domains (LCDs). Interestingly, many factors that regulate microRNA (miRNA) biogenesis and alternative splicing are RNA-binding proteins that contain LCDs and localize to stress-induced liquid-like compartments. Consequently, gene silencing through miRNAs and alternative splicing of pre-mRNAs are emerging as crucial post-transcriptional mechanisms that function on a genome-wide scale to regulate the cellular stress response. In this Review, we describe the interplay between these two post-transcriptional processes that occur in liquid-like compartments as an adaptive cellular response to stress.

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Sprache(n): eng - English
 Datum: 2018-02-142018-02
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1242/jcs.202002
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Titel: Journal of Cell Science
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: 11 Band / Heft: 131 (4) Artikelnummer: jcs202002 Start- / Endseite: - Identifikator: -