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  Dopaminergic modulation of hemodynamic signal variability and the functional connectome during cognitive performance

Alavash, M., Lim, S.-J., Thiel, C., Sehm, B., Deserno, L., & Obleser, J. (2018). Dopaminergic modulation of hemodynamic signal variability and the functional connectome during cognitive performance. NeuroImage, 172, 341-356. doi:10.1016/j.neuroimage.2018.01.048.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-83A8-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A086-0
Genre: Journal Article

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 Creators:
Alavash, Mohsen1, 2, Author              
Lim, Sung-Joo1, 2, Author              
Thiel, Christiane3, Author
Sehm, Bernhard4, Author              
Deserno, Lorenz4, Author              
Obleser, Jonas1, 2, Author              
Affiliations:
1Department of Psychology, University of Lübeck, Germany, ou_persistent22              
2Max Planck Research Group Auditory Cognition, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_751545              
3Department of Psychology, Carl von Ossietzky University of Oldenburg, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Dopamine; BOLD signal variability; Functional connectome; Auditory working memory; Graph theory; fMRI
 Abstract: Dopamine underlies important aspects of cognition, and has been suggested to boost cognitive performance. However, how dopamine modulates the large-scale cortical dynamics during cognitive performance has remained elusive. Using functional MRI during a working memory task in healthy young human listeners, we investigated the effect of levodopa (l-dopa) on two aspects of cortical dynamics, blood oxygen-level-dependent (BOLD) signal variability and the functional connectome of large-scale cortical networks. We here show that enhanced dopaminergic signaling modulates the two potentially interrelated aspects of large-scale cortical dynamics during cognitive performance, and the degree of these modulations is able to explain inter-individual differences in l-dopa-induced behavioral benefits. Relative to placebo, l-dopa increased BOLD signal variability in task-relevant temporal, inferior frontal, parietal and cingulate regions. On the connectome level, however, l-dopa diminished functional integration across temporal and cingulo-opercular regions. This hypo-integration was expressed as a reduction in network efficiency and modularity in more than two thirds of the participants and to different degrees. Hypo-integration co-occurred with relative hyper-connectivity in paracentral lobule and precuneus, as well as posterior putamen. Both, l-dopa-induced BOLD signal variability modulation and functional connectome modulations proved predictive of an individual's l-dopa-induced benefits in behavioral performance, namely response speed and perceptual sensitivity. Lastly, l-dopa-induced modulations of BOLD signal variability were correlated with l-dopa-induced modulation of nodal connectivity and network efficiency. Our findings underline the role of dopamine in maintaining the dynamic range of, and communication between, cortical systems, and their explanatory power for inter-individual differences in benefits from dopamine during cognitive performance.

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Language(s): eng - English
 Dates: 2018-01-152017-09-012018-01-182018-02-022018-05-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2018.01.048
PMID: 29410219
Other: Epub 2018
 Degree: -

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Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : The listening challenge: How ageing brains adapt / AUDADAPT
Grant ID : 646696
Funding program : Horizon 2020
Funding organization : European Commission (EC)

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 172 Sequence Number: - Start / End Page: 341 - 356 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166