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  The murine GABAA receptor δ-subunit gene: structure and assignment to human chromosome 1

Sommer, B., Poustka, A., Spurr, N. K., & Seeburg, P. H. (1990). The murine GABAA receptor δ-subunit gene: structure and assignment to human chromosome 1. DNA and Cell Biology, 9(8), 561-568. doi:10.1089/dna.1990.9.561.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-8430-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-1578-8
Genre: Journal Article

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DNACellBiol_9_1990_561.pdf (Any fulltext), 657KB
 
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http://online.liebertpub.com/doi/pdf/10.1089/dna.1990.9.561 (Any fulltext)
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 Creators:
Sommer, Bernd, Author
Poustka, A., Author
Spurr, N. K., Author
Seeburg, Peter H.1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: The murine chromosomal gene for the GABAA receptor δ subunit was isolated and characterized by high-resolution mapping and DNA sequencing. Spanning 13 kb, it comprises nine exons and displays an intron pattern comparable, but not identical, to that seen in members of the nicotinic acetylcholine receptor family. Notably, the second transmembrane domain thought to line the ion channel and conserved among different GABAA receptor subunits, is interrupted by an intron. The 5′-flanking region of the δ gene displays features characteristic of a CpG island and lacks canonical promoter elements such as TATA and CCAAT consensus sequences in proximity to the transcriptional initiation site. The human δ subunit gene was localized on the short arm of chromosome 1.

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Language(s): eng - English
 Dates: 1990-06-252009-03-251990
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1089/dna.1990.9.561
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Title: DNA and Cell Biology
  Other : DNA Cell Biol.
Source Genre: Journal
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Publ. Info: Larchmont, N.Y. : Mary Ann Liebert
Pages: - Volume / Issue: 9 (8) Sequence Number: - Start / End Page: 561 - 568 Identifier: ISSN: 1044-5498
CoNE: https://pure.mpg.de/cone/journals/resource/954927627228