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  Two novel GABAA receptor subunits exist in distinct neuronal subpopulations

Shivers, B. D., Killisch, I., Sprengel, R., Sontheimer, H., Köhler, M., Schofield, P. R., et al. (1989). Two novel GABAA receptor subunits exist in distinct neuronal subpopulations. Neuron, 3(3), 327-337. doi:10.1016/0896-6273(89)90257-2.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-855D-2 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-855E-1
Genre: Journal Article

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Neuron_3_1989_327.pdf (Any fulltext), 7MB
 
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Shivers, Brenda D., Author
Killisch, Iris1, Author           
Sprengel, Rolf1, 2, 3, Author           
Sontheimer, Harald, Author
Köhler, Martin1, Author           
Schofield, Peter R., Author
Seeburg, Peter H.1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Rolf Sprengel Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497741              
3Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society, ou_1497733              

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 Abstract: Two cDNAs encoding novel GABAA receptor subunits were isolated from a rat brain library. These subunits, gamma 2 and delta, share approximately 35% sequence identity with alpha and beta subunits and form functional GABA-gated chloride channels when expressed alone in vitro. The gamma 2 subunit is the rat homolog of the human gamma 2 subunit recently shown to be important for benzodiazepine pharmacology. Cellular localization of the mRNAs encoding the gamma 2 and delta subunits in rat brain revealed that largely distinct neuronal subpopulations express the two subunits. The delta subunit distribution resembles that of the high affinity GABAA receptor labeled with [3H]muscimol; the gamma 2 subunit distribution resembles that of GABAA/benzodiazepine receptors labeled with [3H]flunitrazepam. These findings have implications for the composition of two different GABAA receptor subtypes and for information processing in networks using GABA for signaling.

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Language(s): eng - English
 Dates: 1989-05-021989-06-262004-04-201989-09-01
 Publication Status: Issued
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0896-6273(89)90257-2
URI: https://www.ncbi.nlm.nih.gov/pubmed/2561970
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 3 (3) Sequence Number: - Start / End Page: 327 - 337 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565