English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  How microstructure changes are associated with gene deletions in psychiatric disorder

Kumar, V. (2015). How microstructure changes are associated with gene deletions in psychiatric disorder. In Donders Discussions 2015 (pp. 22-22).

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-887B-D Version Permalink: http://hdl.handle.net/21.11116/0000-0000-887C-C
Genre: Meeting Abstract

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Kumar, Vinod1, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497796              

Content

show
hide
Free keywords: -
 Abstract: The genetic and epigenetic code of genes procreate the brain structure. Deletion of a single gene can lead to drastic structural changes that can be detected using diffusion MRI. In this study, we investigated structural changes occurred due to deletion of all genes located at locus 16p11.2 in mouse, which are believed to be involved in Schizophrenia. In addition, we hypothesized; male and female mice process the deletion similarly or differently. Thus, to detect the specific white matter micro-structural changes in ultra-high spatial resolution a custom made MR coil was used. Also, the generic diffusion analysis pipeline was adapted for mice. The analysis revealed that deletion of the gene-locus leads to decrease in the fiber integrity in inter-hemispheric communication, which is convergent with gene expression.

Details

show
hide
Language(s):
 Dates: 2015-11-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: -
 Degree: -

Event

show
hide
Title: Donders Discussions 2015
Place of Event: Nijmegen, The Netherlands
Start-/End Date: -

Legal Case

show

Project information

show

Source 1

show
hide
Title: Donders Discussions 2015
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 22 - 22 Identifier: -