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  Expression of nuclear lamins in mammalian somatic cells lacking cytoplasmic intermediate filament proteins

Paulin−Levasseur, M., Scherbarth, A., Giese, G., Roser, K., Bohn, W., & Traub, P. (1989). Expression of nuclear lamins in mammalian somatic cells lacking cytoplasmic intermediate filament proteins. Journal of Cell Science, 92(3), 361-370. Retrieved from http://jcs.biologists.org/content/92/3/361.

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JCellSci_92_1989_361.pdf (Any fulltext), 10MB
 
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Paulin−Levasseur, M., Author
Scherbarth, Annemarie1, 2, Author              
Giese, Günter1, 2, Author              
Roser, K., Author
Bohn, Wolfgang, Author
Traub, Peter, Author
Affiliations:
1Light Microscopy Facility, Max Planck Institute for Medical Research, Max Planck Society, ou_1497720              
2Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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Free keywords: nuclear lamins; intermediate filaments; somatic cells
 Abstract: Using immunofluorescence and immunoblotting techniques, we have examined the composition of the nuclear lamina in murine plasmacytoma cells, MPC-11, exposed to the phorbol ester TPA as well as in two cell lines devoid of cytoplasmic intermediate filament proteins, the human adrenal cortex carcinoma-derived cells SW-13 and the clone C6-M-D4 derived from the rat glial cell line C6. Our results show that the inhibition of proliferation and the induction of vimentin synthesis observed in TPA-treated MPC-11 populations are not paralleled by changes in the lamin complement of these cells, which contain lamin B but lack lamins A and C. Furthermore, the analysis performed on SW-13 and C6-M-D4 cell lines clearly demonstrates that mammalian somatic cells display considerable variations in lamin expression and indicates that lamin B may be the only lamin species constitutively expressed in mammalian cells.

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Language(s): eng - English
 Dates: 1988-08-041988-12-051989-03-011989-03-01
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Journal of Cell Science
Source Genre: Journal
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Publ. Info: Cambridge, U.K. : Co. of Biologists
Pages: - Volume / Issue: 92 (3) Sequence Number: - Start / End Page: 361 - 370 Identifier: ISSN: 0021-9533
CoNE: https://pure.mpg.de/cone/journals/resource/954925326678