English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Non-water-suppressed 1H FID-MRSI at 3T and 9.4T

Chang, P., Nassirpour, S., Avdievich, N., & Henning, A. (2018). Non-water-suppressed 1H FID-MRSI at 3T and 9.4T. Magnetic Resonance in Medicine, 80(2), 442-451. doi:10.1002/mrm.27049.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C26A-E Version Permalink: http://hdl.handle.net/21.11116/0000-0001-3197-D
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Chang, P1, 2, Author              
Nassirpour, S1, 2, Author              
Avdievich, N1, 2, Author              
Henning, A1, 2, Author              
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Purpose This study investigates metabolite concentrations using metabolite-cycled 1H free induction decay (FID) magnetic resonance spectroscopic imaging (MRSI) at ultra-high fields. Methods A non-lipid-suppressed and slice-selective ultra-short echo time (TE) 1H FID MRSI sequence was combined with a low-specific absorption rate (SAR) asymmetric inversion adiabatic pulse to enable non-water-suppressed metabolite mapping using metabolite-cycling at 9.4T. The results were compared to a water-suppressed FID MRSI sequence, and the same study was performed at 3T for comparison. The scan times for performing single-slice metabolite mapping with a nominal voxel size of 0.4 mL were 14 and 17.5 min on 3T and 9.4T, respectively. Results The low-SAR asymmetric inversion adiabatic pulse enabled reliable non-water-suppressed metabolite mapping using metabolite cycling at both 3T and 9.4T. The spectra and maps showed good agreement with the water-suppressed FID MRSI ones at both field strengths. A quantitative analysis of metabolite ratios with respect to N-acetyl aspartate (NAA) was performed. The difference in Cre/NAA was statistically significant, ∼0.1 higher for the non-water-suppressed case than for water suppression (from 0.73 to 0.64 at 3T and from 0.69 to 0.59 at 9.4T). The difference is likely because of chemical exchange effects of the water suppression pulses. Small differences in mI/NAA were also statistically significant, however, are they are less reliable because the metabolite peaks are close to the water peak that may be affected by the water suppression pulses or metabolite-cycling inversion pulse. Conclusion We showed the first implementation of non-water-suppressed metabolite-cycled 1H FID MRSI at ultra-high fields. An increase in Cre/NAA was seen for the metabolite-cycled case. The same methodology was further applied at 3T and similar results were observed.

Details

show
hide
Language(s):
 Dates: 2017-122018-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/mrm.27049
BibTex Citekey: ChangNAH2017
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Magnetic Resonance in Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 80 (2) Sequence Number: - Start / End Page: 442 - 451 Identifier: ISSN: 0740-3194
CoNE: /journals/resource/954925538149