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  Development of visual cortical function in infant macaques: A BOLD fMRI study

Van Grootel, T., Meeson, A., Munk, M., Kourtzi, Z., Movshon, J., Logothetis, N., et al. (2017). Development of visual cortical function in infant macaques: A BOLD fMRI study. PLoS ONE, 12(11), 1-29. doi:10.1371/journal.pone.0187942.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C288-B Version Permalink: http://hdl.handle.net/21.11116/0000-0001-877D-B
Genre: Journal Article

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Van Grootel, TJ1, Author              
Meeson, A, Author
Munk, MHJ, Author              
Kourtzi, Z1, 2, Author              
Movshon, JA, Author
Logothetis, NK1, 3, Author              
Kiorpes, L1, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Department Human Perception, Cognition and Action, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497797              
3Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Functional brain development is not well understood. In the visual system, neurophysiological studies in nonhuman primates show quite mature neuronal properties near birth although visual function is itself quite immature and continues to develop over many months or years after birth. Our goal was to assess the relative development of two main visual processing streams, dorsal and ventral, using BOLD fMRI in an attempt to understand the global mechanisms that support the maturation of visual behavior. Seven infant macaque monkeys (Macaca mulatta) were repeatedly scanned, while anesthetized, over an age range of 102 to 1431 days. Large rotating checkerboard stimuli induced BOLD activation in visual cortices at early ages. Additionally we used static and dynamic Glass pattern stimuli to probe BOLD responses in primary visual cortex and two extrastriate areas: V4 and MT-V5. The resulting activations were analyzed with standard GLM and multivoxel pattern analysis (MVPA) approaches. We analyzed three contrasts: Glass pattern present/absent, static/dynamic Glass pattern presentation, and structured/random Glass pattern form. For both GLM and MVPA approaches, robust coherent BOLD activation appeared relatively late in comparison to the maturation of known neuronal properties and the development of behavioral sensitivity to Glass patterns. Robust differential activity to Glass pattern present/absent and dynamic/static stimulus presentation appeared first in V1, followed by V4 and MT-V5 at older ages; there was no reliable distinction between the two extrastriate areas. A similar pattern of results was obtained with the two analysis methods, although MVPA analysis showed reliable differential responses emerging at later ages than GLM. Although BOLD responses to large visual stimuli are detectable, our results with more refined stimuli indicate that global BOLD activity changes as behavioral performance matures. This reflects an hierarchical development of the visual pathways. Since fMRI BOLD reflects neural activity on a population level, our results indicate that, although individual neurons might be adult-like, a longer maturation process takes place on a population level.

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 Dates: 2017-11
 Publication Status: Published online
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 Identifiers: DOI: 10.1371/journal.pone.0187942
eDoc: e0187942
BibTex Citekey: VanGrootelMMKMLK2017
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Title: PLoS ONE
Source Genre: Journal
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Pages: - Volume / Issue: 12 (11) Sequence Number: - Start / End Page: 1 - 29 Identifier: -