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  Dynamical state transitions into addictive behaviour and their early-warning signals

Foo, J., Noori, H., Yamaguchi, I., Vengeliene, V., Cosa-Linan, A., Nakamura, T., et al. (2017). Dynamical state transitions into addictive behaviour and their early-warning signals. Proceedings of the Royal Society B: Biological Sciences, 284(1860): 20170882, pp. 1-8. doi:10.1098/rspb.2017.0882.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C2C8-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-9B5C-7
Genre: Journal Article

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Foo, JC, Author
Noori, HR1, 2, Author              
Yamaguchi, I, Author
Vengeliene, V, Author
Cosa-Linan, A, Author
Nakamura, T, Author
Morita, K, Author
Spanagel, R, Author
Yamamoto, Y, Author
Affiliations:
1Research Group Neuronal Convergence, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528694              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: The theory of critical transitions in complex systems (ecosystems, climate, etc.), and especially its ability to predict abrupt changes by early-warning signals based on analysis of fluctuations close to tipping points, is seen as a promising avenue to study disease dynamics. However, the biomedical field still lacks a clear demonstration of this concept. Here, we used a well-established animal model in which initial alcohol exposure followed by deprivation and subsequent reintroduction of alcohol induces excessive alcohol drinking as an example of disease onset. Intensive longitudinal data (ILD) of rat drinking behaviour and locomotor activity were acquired by a fully automated drinkometer device over 14 weeks. Dynamical characteristics of ILD were extracted using a multi-scale computational approach. Our analysis shows a transition into addictive behaviour preceded by early-warning signals such as instability of drinking patterns and locomotor circadian rhythms, and a resultant increase in low frequency, ultradian rhythms during the first week of deprivation. We find evidence that during prolonged deprivation, a critical transition takes place pushing the system to excessive alcohol consumption. This study provides an adaptable framework for processing ILD from clinical studies and for examining disease dynamics and early-warning signals in the biomedical field.

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 Dates: 2017-08
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1098/rspb.2017.0882
BibTex Citekey: FooNYVCNMSY2017_2
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Title: Proceedings of the Royal Society B: Biological Sciences
  Abbreviation : Proc. R. Soc. B
Source Genre: Journal
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Publ. Info: London : Royal Society
Pages: - Volume / Issue: 284 (1860) Sequence Number: 20170882 Start / End Page: 1 - 8 Identifier: ISSN: 0962-8452
CoNE: https://pure.mpg.de/cone/journals/resource/110975500577295_2