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  EM connectomics reveals axonal target variation in a sequence-generating network

Kornfeld, J., Benezra, S., Narayanan, R., Svara, F., Egger, R., Oberlaender, M., et al. (2017). EM connectomics reveals axonal target variation in a sequence-generating network. eLIFE, 6(3), 1-20. doi:10.7554/eLife.24364.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C31D-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-857A-0
Genre: Journal Article

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Kornfeld, J, Author
Benezra, SE, Author
Narayanan, RT1, 2, Author              
Svara, F, Author
Egger, R1, 2, Author              
Oberlaender, M1, 2, Author              
Denk, W, Author
Long, MA, Author
Affiliations:
1Former Research Group Computational Neuroanatomy, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528698              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: The sequential activation of neurons has been observed in various areas of the brain, but in no case is the underlying network structure well understood. Here we examined the circuit anatomy of zebra finch HVC, a cortical region that generates sequences underlying the temporal progression of the song. We combined serial block-face electron microscopy with light microscopy to determine the cell types targeted by HVC(RA) neurons, which control song timing. Close to their soma, axons almost exclusively targeted inhibitory interneurons, consistent with what had been found with electrical recordings from pairs of cells. Conversely, far from the soma the targets were mostly other excitatory neurons, about half of these being other HVC(RA) cells. Both observations are consistent with the notion that the neural sequences that pace the song are generated by global synaptic chains in HVC embedded within local inhibitory networks.

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 Dates: 2017-04
 Publication Status: Published online
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 Identifiers: DOI: 10.7554/eLife.24364
eDoc: e24364
BibTex Citekey: KornfeldBNSEODL2017
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Title: eLIFE
Source Genre: Journal
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Pages: - Volume / Issue: 6 (3) Sequence Number: - Start / End Page: 1 - 20 Identifier: -