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  Inhibition decorrelates visual feature representations in the inner retina

Franke, K., Berens, P., Schubert, T., Bethge, M., Euler, T., & Baden, T. (2017). Inhibition decorrelates visual feature representations in the inner retina. Nature, 542(7642), 439-444. doi:10.1038/nature21394.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C33F-E Version Permalink: http://hdl.handle.net/21.11116/0000-0000-F9D0-C
Genre: Journal Article

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Franke, K, Author
Berens, P, Author              
Schubert, T, Author
Bethge, M1, 2, Author              
Euler, T, Author
Baden, T, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group Computational Vision and Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497805              

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 Abstract: The retina extracts visual features for transmission to the brain. Different types of bipolar cell split the photoreceptor input into parallel channels and provide the excitatory drive for downstream visual circuits. Mouse bipolar cell types have been described at great anatomical and genetic detail, but a similarly deep understanding of their functional diversity is lacking. Here, by imaging light-driven glutamate release from more than 13,000 bipolar cell axon terminals in the intact retina, we show that bipolar cell functional diversity is generated by the interplay of dendritic excitatory inputs and axonal inhibitory inputs. The resulting centre and surround components of bipolar cell receptive fields interact to decorrelate bipolar cell output in the spatial and temporal domains. Our findings highlight the importance of inhibitory circuits in generating functionally diverse excitatory pathways and suggest that decorrelation of parallel visual pathways begins as early as the second synapse of the mouse visual system.

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 Dates: 2017-02
 Publication Status: Published in print
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 Identifiers: DOI: 10.1038/nature21394
BibTex Citekey: FrankeBSBEB2017
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Title: Nature
Source Genre: Journal
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Pages: - Volume / Issue: 542 (7642) Sequence Number: - Start / End Page: 439 - 444 Identifier: -