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  Altered task-specific deactivation in the default mode network depends on valence in patients with major depressive disorder

Zhang, B., Li, S., Zhuo, C., Li, M., Safron, A., Genz, A., et al. (2017). Altered task-specific deactivation in the default mode network depends on valence in patients with major depressive disorder. Journal of Affective Disorders, 207, 377-383. doi:10.1016/j.jad.2016.08.042.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C34F-C Version Permalink: http://hdl.handle.net/21.11116/0000-0000-C78B-3
Genre: Journal Article

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Zhang, B, Author
Li, S, Author
Zhuo, C, Author
Li, M, Author
Safron, A, Author
Genz, A, Author
Qin, W, Author
Yu, C, Author
Walter, M1, Author              
Affiliations:
1Department of Psychiatry and Psychotherapy, University Tübingen, Tübingen, Germany, ou_persistent22              

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 Abstract: Background Major depressive disorder (MDD) is a highly prevalent psychiatric condition in which patients often have difficulties regulating their emotions. Prior studies have shown that attention bias towards negative emotion is linked to activation in regions of the default mode network (DMN) in MDD individuals. Furthermore, MDD patients showed increased resting-state functional connectivity (FC) between the medial prefrontal cortex and other DMN structures. Methods Twenty-one MDD patients that currently experiencing depressive episodes and twenty-five healthy control participants performed the current emotional expectancy paradigm in a gradient-echo SENSE-SPIRAL fMRI. Whole brain and psycho-physiological interaction (PPI) analysis were applied to explore the task-related brain activity and FCs. Results Relative to healthy participants, we found MDD patients had greater activity in dorsal medial prefrontal cortex as a function of positive vs. neutral expectancy conditions. PPI results revealed a significant group difference of MDD patients having relatively decreased task-dependent decoupling from dorsal medial prefrontal cortex (DMPFC) towards posterior cingulate cortex (PCC) and parieto-occipital cortex during positive vs. neutral expectancy conditions, and patients exhibited a positive correlation between PPI (DMPFC and PCC) and anhedonia as measured via SHAPS during the same conditions. Limitations Modest sample size and lack of concurrent depressive episodes limit the generalizability of our findings. Conclusions In MDD patients, insufficient DMN decoupling might occur in response to positive expectancy conditions. Our findings are consistent with the hypothesis that high intrinsic DMN connectivity in MDD patients interfere with the down-regulation of intrinsic focus in order to incorporate information derived from external positive events.

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 Dates: 2017-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.jad.2016.08.042
BibTex Citekey: ZhangLZLSGQYW2017
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Title: Journal of Affective Disorders
Source Genre: Journal
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Pages: - Volume / Issue: 207 Sequence Number: - Start / End Page: 377 - 383 Identifier: -