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  Mechanisms of SNR and line shape improvement by B0 correction in overdiscrete MRSI reconstruction

Kirchner, T., Fillmer, A., & Henning, A. (2017). Mechanisms of SNR and line shape improvement by B0 correction in overdiscrete MRSI reconstruction. Magnetic Resonance in Medicine, 77(1), 44-56. doi:10.1002/mrm.26118.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C35D-C Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1EF7-8
Genre: Journal Article

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Kirchner, T, Author
Fillmer, A, Author
Henning, A1, 2, Author              
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1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              

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 Abstract: Purpose Inhomogeneities of the main magnetic field cause line broadening and location-dependent frequency shifts in brain MRSI. These are often visible despite advanced B0 shimming. The purpose of this work is to propose an advanced B0 correction method that can easily be applied during postprocessing. Methods A target-driven overdiscrete reconstruction method previously introduced for MRSI is modified by dividing it into two steps. In a first step, an intermediate spectroscopic image with arbitrarily high resolution is generated, on which B0 correction is performed as an additional processing step based on an additionally acquired B0 map. This frequency-aligns metabolite peaks and destroys noise correlations between neighboring subvoxels. Second, the voxel is shaped by application of the spatial response target. The method was tested with simulated spectroscopic imaging data as well as in a series of MRSI data sets obtained from four healthy volunteers at 7T. Results A systematic gain in spectral signal-to-noise ratio is achieved, due to spatial averaging now occurring over peak aligned and noise decorrelated subvoxel spectra. At the same time, metabolite peak line widths are reduced. Conclusion In the presence of B0 inhomogeneities across the field of view, the proposed method offers the potential to improve spectral quality with only a minimal additional effort during acquisition.

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 Dates: 2017-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.26118
BibTex Citekey: KirchnerFH2016
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 77 (1) Sequence Number: - Start / End Page: 44 - 56 Identifier: -