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  Robust Detection of Impaired Resting State Functional Connectivity Networks in Alzheimer's Disease Using Elastic Net Regularized Regression

Teipel, S., Grothe, M., Metzger, C., Grimmer, T., Sorg, C., Ewers, M., et al. (2017). Robust Detection of Impaired Resting State Functional Connectivity Networks in Alzheimer's Disease Using Elastic Net Regularized Regression. Frontiers in Aging Neuroscience, 8(318), 1-9. doi:10.3389/fnagi.2016.00318.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C363-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-C754-1
Genre: Journal Article

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Teipel, SJ, Author
Grothe, MJ, Author
Metzger, CD, Author
Grimmer, T, Author
Sorg, C, Author
Ewers, M, Author
Franzmeier, N, Author
Meisenzahl, E, Author
Klöppel, S, Author
Borchardt, V, Author
Walter, M1, Author              
Dyrba, M, Author
Affiliations:
1Department of Psychiatry, University of Tübingen, ou_persistent22              

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 Abstract: The large number of multicollinear regional features that are provided by resting state (rs) fMRI data requires robust feature selection to uncover consistent networks of functional disconnection in Alzheimer's disease (AD). Here, we compared elastic net regularized and classical stepwise logistic regression in respect to consistency of feature selection and diagnostic accuracy using rs-fMRI data from four centers of the “German resting-state initiative for diagnostic biomarkers” (psymri.org), comprising 53 AD patients and 118 age and sex matched healthy controls. Using all possible pairs of correlations between the time series of rs-fMRI signal from 84 functionally defined brain regions as the initial set of predictor variables, we calculated accuracy of group discrimination and consistency of feature selection with bootstrap cross-validation. Mean areas under the receiver operating characteristic curves as measure of diagnostic accuracy were 0.70 in unregularized and 0.80 in regularized regression. Elastic net regression was insensitive to scanner effects and recovered a consistent network of functional connectivity decline in AD that encompassed parts of the dorsal default mode as well as brain regions involved in attention, executive control, and language processing. Stepwise logistic regression found no consistent network of AD related functional connectivity decline. Regularized regression has high potential to increase diagnostic accuracy and consistency of feature selection from multicollinear functional neuroimaging data in AD. Our findings suggest an extended network of functional alterations in AD, but the diagnostic accuracy of rs-fMRI in this multicenter setting did not reach the benchmark defined for a useful biomarker of AD.

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 Dates: 2017-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.3389/fnagi.2016.00318
BibTex Citekey: TeipelGMGSEFMKBWD2017
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Title: Frontiers in Aging Neuroscience
Source Genre: Journal
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Pages: - Volume / Issue: 8 (318) Sequence Number: - Start / End Page: 1 - 9 Identifier: -