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  Towards CMOS-based in-vivo NMR spectroscopy and microscopy

Handwerker, J., Pérez-Rodas, M., Ortmanns, M., Scheffler, K., & Anders, J. (2017). Towards CMOS-based in-vivo NMR spectroscopy and microscopy. In IEEE International Symposium on Circuits & Systems (ISCAS 2017) (pp. 1-4). Piscataway, NJ, USA: IEEE.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C3B5-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-C3B6-6
Genre: Conference Paper

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 Creators:
Handwerker, J, Author
Pérez-Rodas, M1, 2, Author              
Ortmanns, M, Author
Scheffler, K1, 2, Author              
Anders, J, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: In this paper, we discuss the requirements for an NMR setup to allow for combined NMR microscopy and spectroscopy using planar microcoils to study metabolic processes in vivo. Here, NMR is particularly suitable because — unlike most other currently used methods — it can deliver structural information as well as qualitative and quantitative information about the molecules involved in cellular processes. More specifically, based on the reciprocity principle, we derive why previously presented fully-integrated CMOS receivers using on-chip NMR coils in receive-only mode are not suitable for in-vivo spectroscopy applications. As a solution to this problem, we propose the use of fully-integrated transceivers which use their on-chip planar microcoils in TX/RX mode as an ideal tool for combined in-vivo NMR imaging and spectroscopy. Measurements using a planar coil on a thin silicon substrate validate the theoretical analysis.

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 Dates: 2017-05
 Publication Status: Published in print
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 Identifiers: DOI: 10.1109/ISCAS.2017.8049753
BibTex Citekey: HandwerkerPOSA2017
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Title: IEEE International Symposium on Circuits Systems (ISCAS 2017)
Place of Event: Baltimore, MD, USA
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Title: IEEE International Symposium on Circuits & Systems (ISCAS 2017)
Source Genre: Proceedings
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Publ. Info: Piscataway, NJ, USA : IEEE
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 1 - 4 Identifier: ISBN: 978-1-4673-6852-0