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  When Photons Meet Protons: Optogenetics, Calcium Signal Detection, and fMRI in Small Animals

Yu, X. (2017). When Photons Meet Protons: Optogenetics, Calcium Signal Detection, and fMRI in Small Animals. In F. Kiessling, B. Pichler, & P. Hauff (Eds.), Small Animal Imaging: Basics and Practical Guide (pp. 773-791). Cham, Switzerland: Springer.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C3CB-F Version Permalink: http://hdl.handle.net/21.11116/0000-0000-FAFF-8
Genre: Book Chapter

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 Creators:
Yu, X1, 2, 3, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528695              

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 Abstract: In the new era of brain research, highlighted by the Human Brain Project and BRAIN Initiative, how to link the cellular, circuit, and system aspects of brain function is one of the key aims of this mission. The multimodal neuroimaging methodology has provided us a promising platform. Among the numerous efforts on brain functional mapping, the combination of optogenetics, calcium signal detection by genetically encoded indictors, and functional magnetic resonance imaging (fMRI) presents a unique perspective to better understand brain function. This chapter will focus on the recent application of optogenetic tools for fMRI studies, as well as a recent development of the fiber optic-mediated simultaneous calcium recording with fMRI. These studies lead to a new concept, the single unit of neurovascular coupling (SUNC) (Fig. 31.1), to better understand the signal propagation through the neuron-glia-vessel network in the brain of rodents.

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 Dates: 2017-05
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1007/978-3-319-42202-2_31
BibTex Citekey: Yu2017
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Title: Small Animal Imaging: Basics and Practical Guide
Source Genre: Book
 Creator(s):
Kiessling, F., Editor
Pichler, B.J., Editor
Hauff, P., Editor
Affiliations:
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Publ. Info: Cham, Switzerland : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 773 - 791 Identifier: ISBN: 978-3-319-42200-8