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  Pharmaco-Based fMRI and Neurophysiology in Non-human Primates

Zaldivar, D., Logothetis, N., Rauch, A., & Goense, J. (2017). Pharmaco-Based fMRI and Neurophysiology in Non-human Primates. In A. Philippu (Ed.), In Vivo Neuropharmacology and Neurophysiology (pp. 37-66). New York, NY, USA: Springer.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C3CF-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-FEBD-B
Genre: Book Chapter

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 Creators:
Zaldivar, D1, 2, Author              
Logothetis, NK1, 2, Author              
Rauch, A1, Author              
Goense, J1, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Brain activity is continuously changing, among others reflecting the effects of neuromodulation on multiple spatial and temporal scales. By altering the input–output relationship of neural circuits, neuromodulators can also affect their energy expenditure, with concomitant effects on the hemodynamic responses. Yet, it is still unclear how to study and interpret the effects of different neuromodulators, for instance, how to differentiate their effects from underlying behavior- or stimulus-driven activity. Gaining insights into neuromodulatory processes is largely hampered by the lack of approaches providing information concurrently at different spatio-temporal scales. Here, we provide an overview of the multimodal approach consisting of functional magnetic resonance imaging (fMRI), pharmacology and neurophysiology, which we developed to elucidate causal relationships between neuromodulation and neurovascular coupling in visual cortex of anesthetized macaques.

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 Dates: 2017
 Publication Status: Published in print
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 Identifiers: DOI: 10.1007/978-1-4939-6490-1_3
BibTex Citekey: ZaldivarLG2017
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Title: In Vivo Neuropharmacology and Neurophysiology
Source Genre: Book
 Creator(s):
Philippu, A, Editor
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Publ. Info: New York, NY, USA : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 37 - 66 Identifier: ISBN: 978-1-4939-6488-8

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Title: Neuromethods
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Pages: - Volume / Issue: 121 Sequence Number: - Start / End Page: - Identifier: -