English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Cervical spinal cord and brain magnetic resonance spectroscopy alterations in normal appearing white matter of multiple sclerosis (MS) patients at 3T

Wyss, P., Hock, A., Lutterotti, A., Martin, R., Kollias, S., & Henning, A. (2017). Cervical spinal cord and brain magnetic resonance spectroscopy alterations in normal appearing white matter of multiple sclerosis (MS) patients at 3T. Poster presented at CRPP Symposium 2017: Heterogeneity of Autoimmune Diseases, Zürich, Switzerland.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C473-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-FEE0-5
Genre: Poster

Files

show Files

Locators

show
hide
Locator:
Link (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Wyss, P1, 2, Author              
Hock, A, Author
Lutterotti, A, Author
Martin, R, Author
Kollias, S, Author
Henning, A1, 2, Author              
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Anatomical MRI findings has limited value in predicting patient clinical status or the future course of the disease. Magnetic resonance spectroscopy (MRS) provides the means of accessing biochemical information from the neural tissue thus holding potential for better characterization of the disease and clinical decision-making. In this study, we examined metabolic alterations in the normal appearing white matter (NAWM) of both the brain (periventricular NAWM) and the cervical spinal cord (SC) at C3/C4 in different subgroups of MS. We measured spectra in 15 healthy controls (HC), 28 relapsing-remitting MS (RRMS) and 5 secondary progressive MS (SPMS) patients. The RRMS group is subdivided into three groups based on whether the expanded disability status scale (EDSS) has decreased (RRMSd), increased (RRMSi) or been stable (RRMSs) within the last 12 months prior to the MRS examination. Concentration differences between HC and the patient groups were observed in SC and B for tNAA/tCho (SC/B:p=[0.003,0.011]) and tCho/Cr (SC/B:p=[0.01,0.006]). Additionally, in brain only, differences were found for tNAA/Cr (p=0.027), mI/Cr (p=0.08), Glu/Cr (p=0.016) and tNAA/mI (p=0.05) ratios. Statistical significant differences (false discovery rate corrected) occur between HC and RRMSi in tNAA/tCho (SC/B: p=[0.003,0.017]) and tCho/Cr (SC/B: p=[0.019,0.007]. HC and RRMSs have a significantly different tNAA/tCho (SC: p=0.003]) and tCho/Cr (SC: p=0.019) ratio. RRMSi and SPMS differ in the brain Glu/Cr ratio (p=0.028) and RRMSi and RRMSs have different brain tCho/Cr ratio (p=0.007). tNAA/tCho of the SC significantly correlates with tNAA/tCho of the brain (p<0.001). Changed concentration values detected by MRS may be an indicator of altered metabolism in NAWM of MS patients reflecting inflammation and neurodegeneration or an aggressive course of RRMS. We observed changes in metabolite ratios such as tCho/Cr or tNAA/tCho in both brain and SC. Metabolites including tNAA, Glu, tCho and mI seem to have discriminative power with regard to distinguishing MS subgroups. tNAA/tCho might be a marker of global metabolic abnormalities in NAWM of MS patients. The sensitivity of brain and SC MRS to distinguish clinical subgroups of RRMS with a difference in previous EDSS scores evolvement holds the potential for the use of MRS in therapy monitoring.

Details

show
hide
Language(s):
 Dates: 2017-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: BibTex Citekey: WyssHLMKH2017
 Degree: -

Event

show
hide
Title: CRPP Symposium 2017: Heterogeneity of Autoimmune Diseases
Place of Event: Zürich, Switzerland
Start-/End Date: -

Legal Case

show

Project information

show

Source 1

show
hide
Title: CRPP Symposium 2017: Heterogeneity of Autoimmune Diseases
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 53 - 53 Identifier: -