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  Deciphering the functional projections of the lateral hypothalamus with optogenetic fMRI

Schluesener, J., & Yu, X. (2017). Deciphering the functional projections of the lateral hypothalamus with optogenetic fMRI. Poster presented at 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C48B-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-FB03-2
Genre: Poster

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Schluesener, J1, 2, Author              
Yu, X2, 3, Author              
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1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528695              

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 Abstract: The lateral hypothalamus (LH) is a central node of the brain to mediate brain states. It is comprised of highly heterogeneous neuronal populations and diverse projections. It remains elusive how different neuronal LH subdivisions mediate the brain state. Here, we developed an optogenetic method to map LH functional projections and investigate functional connectivity upon LH activation. Optical stimulation of the LH can directly activate the preoptic area, central thalamus and the subiculum area, and increase the cortical resting-state correlation. This work makes it possible to further target different LH neuronal populations and decipher cell-type specific functional projections.

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 Dates: 2017-04-27
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: SchluesenerY2017
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Title: 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017)
Place of Event: Honolulu, HI, USA
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Title: 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 5321 Start / End Page: - Identifier: -