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  Monitoring neoadjuvant chemotherapy in breast cancer patients using CEST and 31P-MRS at 7 tesla

Krikken, E., Khlebnikov, V., Zaiss, M., van der Kemp, W., van der Velden, T., van Laarhoven, H., et al. (2017). Monitoring neoadjuvant chemotherapy in breast cancer patients using CEST and 31P-MRS at 7 tesla. Poster presented at 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-C4D9-E Version Permalink: https://hdl.handle.net/21.11116/0000-0000-F32C-D
Genre: Poster

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 Creators:
Krikken, E, Author
Khlebnikov, V, Author
Zaiss, M1, 2, Author           
van der Kemp, WJM, Author
van der Velden, TA, Author
van Laarhoven, HWM, Author
Klomp, DWJ, Author
Wijnen, JP, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Treatment monitoring is of importance for breast cancer patients receiving systemic therapy. Metabolic imaging methods such as CEST and 31P-MRS may have potential to predict treatment efficacy in an early stage of the treatment. In this study we assessed the amide proton transfer (APT) signal and the pH change in breast cancer patients before and after the first cycle of neoadjuvant chemotherapy to explore the relation between APT and pH. We observed changes in both the APT signal and the pH between the two measurements. These changes may serve as biomarkers for predicting treatment response to NAC in an early stage.

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 Dates: 2017-04-24
 Publication Status: Issued
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 Identifiers: BibTex Citekey: KrikkenKZvvvKW2017
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Title: 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017)
Place of Event: Honolulu, HI, USA
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Title: 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 3747 Start / End Page: - Identifier: -