English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Decipher the concurrent bidirectional regulation of the fMRI signal by astrocytes

Wang, H., He, Y., Sejnowski, T., & Yu, X. (2017). Decipher the concurrent bidirectional regulation of the fMRI signal by astrocytes. In 47th Annual Meeting of the Society for Neuroscience (Neuroscience 2017).

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C524-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-FEAD-0
Genre: Meeting Abstract

Files

show Files

Locators

show
hide
Locator:
Link (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Wang, H1, 2, Author              
He, Y1, 2, Author              
Sejnowski, TJ, Author
Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Astrocytic Ca2+-mediated gliovascular interactions regulate the neurovascular network in situ and in vivo. However, it is difficult to measure directly both the astrocytic activity and fMRI to relate the various forms of BOLD signaling to brain states under normal and pathological conditions. In this study, fMRI and GCaMP-mediated Ca2+ optical fiber recordings revealed distinct evoked astrocytic Ca2+ signals that were coupled with positive BOLD signals and intrinsic astrocytic Ca2+ signals that were coupled with negative BOLD signals (Fig 1). Furthermore, the evoked and intrinsic astrocytic Ca2+ signal could occur concurrently to mediate positive or negative BOLD signal changes respectively. Unlike propagating Ca2+ waves in spreading depolarization/depression, the intrinsic Ca2+ spikes occurred simultaneously in both hemispheres and were initiated upon the activation of the central thalamus and midbrain reticular formation (Fig 2). These results reveal a crucial role for astrocytes in mediating bidirectional fMRI signals based on the thalamic regulation of cortical states, providing a better understanding of how the BOLD signal is linked to brain activity at the cellular, circuit, and systems levels.

Details

show
hide
Language(s):
 Dates: 2017-11-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: BibTex Citekey: WangHSY2017
 Degree: -

Event

show
hide
Title: 47th Annual Meeting of the Society for Neuroscience (Neuroscience 2017)
Place of Event: Washington, DC, USA
Start-/End Date: -

Legal Case

show

Project information

show

Source 1

show
hide
Title: 47th Annual Meeting of the Society for Neuroscience (Neuroscience 2017)
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: 734.02 Start / End Page: - Identifier: -