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  Distortion and prospective motion corrected zoomed functional imaging of the human brain at 9.4 Tesla

Bause, J., Aghaeifar, A., In, M.-H., Engel, E.-M., Ehses, P., Eschelbach, M., et al. (2017). Distortion and prospective motion corrected zoomed functional imaging of the human brain at 9.4 Tesla. Magnetic Resonance Materials in Physics, Biology and Medicine, 30(Supplement 1), S125-S126.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C53A-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-FA08-E
Genre: Meeting Abstract

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Bause, J1, 2, Author              
Aghaeifar, A1, 2, Author              
In, M-H, Author
Engel, E-M, Author
Ehses, P2, Author              
Eschelbach, M1, 2, Author              
Scheffler, K1, 2, Author              
Pohmann, R1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Purpose/Introduction: Sub-millimeter single-shot echo-planar imaging at ultra-high field is challenging due to stronger distortions evoked by increased B0-inhomogeneities as well as increased blurring and a reduction of the echo-time yielding the maximum BOLD contrast caused by faster T2 * relaxation. Therefore, a shorter echo-train length (ETL) is required, either by utilizing partial Fourier acquisition or parallel imaging techniques. A further reduction of the ETL can be achieved with the reduced field of view (rFOV) method [1]. But even highly accelerated images can suffer from distortions which can be accurately measured and corrected by the point-spread-function (psf) mapping technique [2, 3]. Another issue of high resolution fMRI, is the increased vulnerability to subject motion. Here, we combined rFOV imaging with psf distortion correction and prospective motion correction for high-resolution functional imaging at 9.4 Tesla. Subjects and Methods: Measurements were performed on a whole body scanner (Siemens Healthcare, Germany) using a 16-Tx/31-Rx array [4]. An outer volume suppression pulse was implemented in an EPI sequence [1]. The slice positions of the psf-mapping and functional measurements were updated using data from a camera (Metria Innovation Inc., USA) which tracked a moire´ phase marker fixed to the subject’s bite bar [6]. Parameters: TR = 2000 ms, TE = 25 ms, FA = 80, GRAPPA = 3 (FLEET ACS-scan, [7]), 6/8 partial Fourier, FoV = 150 9 75 mm2, 17 slices, 0.65 mm isotropic, ETL = 36 ms. Paradigm: 20 periods, 10 s flickering circular checkerboard (8 Hz, 7 visual field) + 26.5 s isolimuninant background. Images were reconstructed using in-house developed Matlab routines. From the fMRI data, residual motion was estimated before distortion correction. Results: Although the short ETL used here resulted in already quite small distortions (Fig. 1: a,b), a clear improvement of anatomical matching can be seen when the distortion correction is applied (Fig. 1: c). According to the camera data, the subject presented here moved less than 0.24 mm/0.57. However, the retrospective estimate was even smaller (max. 0.21 mm/0.09). Discussion/Conclusion: We demonstrated anatomically matching sub-millimeter fMRI with reduced interpolation blurring due to avoiding retrospective motion correction. In addition, the echo-train length was shortened in order to limit T2 * -blurring. However, the increased SAR caused by the additional outer volume suppression required a reduction of the number of slices. To reduce SAR, implementation of static B1 +-shimming or even 2D-selective excitation may help [7]. Nevertheless, the presented approach can probably help to investigate the actual resolution of single-shot EPI at high field and can possibly be also used for measuring differences in functional layers.

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 Dates: 2017-10-19
 Publication Status: Published in print
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 Identifiers: DOI: 10.1007/s10334-017-0632-1
BibTex Citekey: BauseAIEEESP2017
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Title: 34th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2017)
Place of Event: Barcelona, Spain
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Title: Magnetic Resonance Materials in Physics, Biology and Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 30 (Supplement 1) Sequence Number: - Start / End Page: S125 - S126 Identifier: -