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  Somatosensory BOLD fMRI reveals close link between salient blood pressure changes and the murine neuromatrix

Reimann, H. M., Todiras, M., Hodge, R., Huelnhagen, T., Millward, J. M., Turner, R., et al. (2018). Somatosensory BOLD fMRI reveals close link between salient blood pressure changes and the murine neuromatrix. NeuroImage, 172, 562-574. doi:10.1016/j.neuroimage.2018.02.002.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-8E83-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-75AC-8
Genre: Journal Article

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 Creators:
Reimann, Henning Matthias1, Author
Todiras, Mihail2, Author
Hodge, Russ2, Author
Huelnhagen, Till1, Author
Millward, Jason Michael1, Author
Turner, Robert3, 4, Author              
Seeliger, Erdmann5, Author
Bader, Michael2, 6, 7, Author
Pohlmann, Andreas1, Author
Niendorf, Thoralf1, 6, 8, Author
Affiliations:
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, Germany, ou_persistent22              
2Max Delbrück Center for Molecular Medicine, Berlin, Germany, ou_persistent22              
3Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
4Faculty of Medicine, University of Amsterdam, the Netherlands, ou_persistent22              
5Institute of Vegetative Physiology, Charité University Medicine Berlin, Germany, ou_persistent22              
6Clinic of Endocrinolgy, Diabetes and Nutrition, Charité University Medicine Berlin, Germany, ou_persistent22              
7German Centre for Cardiovascular Research, Berlin, Germany, ou_persistent22              
8Experimental and Clinical Research Centre, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Mouse; BOLD fMRI; Mean arterial blood pressure; Pain matrix; Pial veins; Somatosensation; Electrical stimulation
 Abstract: The neuromatrix, or “pain matrix”, is a network of cortical brain areas which is activated by noxious as well as salient somatosensory stimulation. This has been studied in mice and humans using blood oxygenation level-dependent (BOLD) fMRI. Here we demonstrate that BOLD effects observed in the murine neuromatrix in response to salient somatosensory stimuli are prone to reflect mean arterial blood pressure (MABP) changes, rather than neural activity. We show that a standard electrostimulus typically used in murine somatosensory fMRI can induce substantial elevations in MABP. Equivalent drug-induced MABP changes — without somatosensory stimulation — evoked BOLD patterns in the neuromatrix strikingly similar to those evoked by electrostimulation. This constitutes a serious caveat for murine fMRI. The regional specificity of these BOLD patterns can be attributed to the co-localization of the neuromatrix with large draining veins. Based on these findings we propose a cardiovascular support mechanism whereby abrupt elevations in MABP provide additional energy supply to the neuromatrix and other essential brain areas in fight-or-flight situations.

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Language(s): eng - English
 Dates: 2017-08-242018-02-012018-02-052018-05-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2018.02.002
PMID: 29421323
Other: Epub 2018
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 172 Sequence Number: - Start / End Page: 562 - 574 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166