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  The role of Locus Coeruleus for sensory processing within mesocortical dopaminergic pathway

Eschenko, O. (2015). The role of Locus Coeruleus for sensory processing within mesocortical dopaminergic pathway. Talk presented at SFB 874 / IGSN Conference: Cortical and Subcortical Representation of Sensory and Cognitive Memory. Bochum, Germany. 2015-04-28 - 2015-04-29.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-AE86-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-D5AE-8
Genre: Talk

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Eschenko, Oxana1, 2, Author              
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1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Salient events evoke burst-like responses of noradrenergic (NE) neurons of the Locus Coeruleus (LC) and dopaminergic (DA) neurons of the ventral tegmenta l area (VTA). The associated NE and DA release modulates information processing in the projection targets of LC and VTA. In the rat, terminal fields of both LC-NE and VTA-DA neurons converge in the medial pref rontal cortex (mPFC), a cortical area controlling many cognitive capacities. We investigated the role of LC phasic activation for sensory responses in VTA and mPFC. Under urhetaine anestesia, noxious stimulatio n (foot shock, FS) produces a robust short-latency (~20 ms) excitation of LC-NE neurons. In VTA and mPFC, the firing rate modulation induced by FS was present in ~30% of neurons. We classified FS-ind uced responses of VTA neurons according to latency (early: ~40 ms or late: ~150 ms) and duration (phasic: < 300 ms or sustained: > 300 ms). Similarly, the mPFC single-unit responses differed by latency and/or duration. Supression of LC ongoing and FS-evoked activity by iontophoretic injection of clonidine, an alpha2-adrenergic receptor agonist, reduced responsiveness in both VTA and mPFC. Population of initially ‘non-responsive’ mPFC neurons showed ‘gating-effect’. Spontaneous disc harge of substantial proportion of VTA and mPFC neurons was bidirectionally modulated. These results suggest that depending on the motivation al valence of a salient event, LC phasic activation and associated NE releas e may selectively enhance or supress signalling within different and, possibly competing mesolimbic and meso cortical pathways. The behavioral data supporting this hypothesis will be presented.

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 Dates: 2015-04
 Publication Status: Published online
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Title: SFB 874 / IGSN Conference: Cortical and Subcortical Representation of Sensory and Cognitive Memory
Place of Event: Bochum, Germany
Start-/End Date: 2015-04-28 - 2015-04-29
Invited: Yes

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