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  Exploring new routes for secretory protein export from the trans-Golgi network

Pakdel, M., & von Blume, J. (2018). Exploring new routes for secretory protein export from the trans-Golgi network. Molecular Biology of the Cell, 29(3), 235-240. doi:10.1091/mbc.E17-02-0117.

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Mol. Biol. Cell-2018-Pakdel-235-40.pdf (Publisher version), 2MB
 
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 Creators:
Pakdel, Mehrshad1, Author              
von Blume, Julia1, Author              
Affiliations:
1von Blume, Julia / Molecular Basis of Protein Trafficking, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565173              

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Free keywords: MANNOSE 6-PHOSPHATE RECEPTOR; GPI-ANCHORED PROTEINS; ENDOPLASMIC-RETICULUM; MEMBRANE-COMPONENTS; GRANULE BIOGENESIS; COATED VESICLES; VGF PEPTIDES; LIM-KINASE; CARGO; ACTINCell Biology;
 Abstract: Sorting of soluble proteins for transport to intracellular compartments and for secretion from cells is essential for cell and tissue homeostasis. The trans-Golgi network (TGN) is a major sorting station that sorts secretory proteins into specific carriers to transport them to their final destinations. The sorting of lysosomal hydrolases at the TGN by the mannose 6-phosphate receptor is well understood. The recent discovery of a Ca2+-based sorting of secretory cargo at the TGN is beginning to uncover the mechanism by which cells sort secretory cargoes from Golgi residents and cargoes destined to the other cellular compartments. This Ca2+-based sorting involves the cytoplasmic actin cytoskeleton, which through membrane anchored Ca2+ ATPase SPCA1 and the luminal Ca2+ binding protein Cab45 sorts of a subset of secretory proteins at the TGN. We present this discovery and highlight important challenges that remain unaddressed in the overall pathway of cargo sorting at the TGN.

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Language(s): eng - English
 Dates: 2018-02-01
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000423608600001
DOI: 10.1091/mbc.E17-02-0117
 Degree: -

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Project name : project grant (BL 1186/4-1)
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Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: Molecular Biology of the Cell
  Other : Mol. Biol. Cell
Source Genre: Journal
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Publ. Info: American Society for Cell Biology
Pages: - Volume / Issue: 29 (3) Sequence Number: - Start / End Page: 235 - 240 Identifier: ISSN: 1059-1524
CoNE: https://pure.mpg.de/cone/journals/resource/954927716372_1